{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T05:06:26Z","timestamp":1733807186140,"version":"3.30.1"},"reference-count":0,"publisher":"Ayub Medical College, Abbottabad Pakistan","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ayub Med Coll Abbottabad"],"abstract":"<jats:p>Background: Thalassemia has high prevalence and carrier rate of 8 - 10% in Pakistan, repeated blood\u00a0 transfusions lead to iron\u00a0 deposition\u00a0 in\u00a0 organs. In this Prospective study we have compared\u00a0 the efficacy\u00a0 of three\u00a0 chelation\u00a0 regimens being used in\u00a0 our country. It has been conducted at PBTS, Fatmid\u00a0 Foundation and Children\u00a0\u00a0 Hospital\u00a0 Lahore. Methods:\u00a0 60 thalassemia\u00a0 major\u00a0 patients, were divided\u00a0 into\u00a0 3\u00a0 groups according\u00a0 to\u00a0 their\u00a0 mode\u00a0 of chelation. \u00a0Patients in group\u00a0 I\u00a0 were on oral\u00a0 iron\u00a0 chelator\u00a0 deferiprone, 7\u00a0 days\u00a0 per\u00a0 week. Thalassemics\u00a0 in\u00a0 group\u00a0 II\u00a0 were on parenteral\u00a0 iron\u00a0 chelator\u00a0 deferoxamine\u00a0 given\u00a0 subcutaneously\u00a0 for\u00a0 4\u00a0 days in a week, and group\u00a0 III\u00a0 patients\u00a0 were on\u00a0 combination\u00a0 therapy, deferiprone for 5 days &amp; deferoxamine\u00a0 given\u00a0 twice\u00a0 weekly.\u00a0 The\u00a0 assessment\u00a0 of\u00a0 chelation\u00a0 was\u00a0 done\u00a0 by\u00a0 measurement\u00a0 of\u00a0 serum\u00a0 ferritin and\u00a0 24\u00a0 hour urinary\u00a0 iron\u00a0 excretion\u00a0 at\u00a0 the\u00a0 start\u00a0 of study\u00a0 and then\u00a0 after\u00a0 six\u00a0 months\u00a0 of\u00a0 follow\u00a0 up.\u00a0 To\u00a0 assess\u00a0 the\u00a0 hepatic\u00a0 iron, \u00a0hepatic\u00a0 MRI\u00a0 were\u00a0 also\u00a0 performed. \u00a0Results: \u00a0\u00a0Ferritin\u00a0 levels were\u00a0 maximally\u00a0 decreased\u00a0 in\u00a0 group\u00a0 II,\u00a0 followed\u00a0 by\u00a0 group\u00a0 III, with\u00a0 no\u00a0 significant\u00a0 reduction in group\u00a0 I. However\u00a0 statistically\u00a0 significant\u00a0 difference\u00a0 in\u00a0 mean\u00a0 urinary\u00a0 iron\u00a0 excretion (increased) was\u00a0 seen\u00a0 in\u00a0 group III. The\u00a0 hepatic\u00a0 iron\u00a0 was\u00a0 very\u00a0 high\u00a0 in\u00a0 all\u00a0 three\u00a0 groups\u00a0 as\u00a0 shown\u00a0 by\u00a0 the\u00a0 hepatic\u00a0 MRI.\u00a0Conclusion: Combination\u00a0 chelation\u00a0 therapy\u00a0 is\u00a0 the\u00a0 most\u00a0 effective\u00a0 chelation\u00a0 therapy\u00a0 in\u00a0 iron\u00a0 overloaded patients. It helps\u00a0 improve\u00a0 the\u00a0 compliance and increases urinary iron excretion. Patients on DFX\u00a0 have\u00a0 lowest\u00a0 degree\u00a0 of\u00a0 hepatic\u00a0 siderosis\u00a0\u00a0 even\u00a0 though\u00a0 it is\u00a0 considerably\u00a0 higher\u00a0 than\u00a0 normal\u00a0 population.<\/jats:p>","DOI":"10.55519\/jamc-01-12436","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T10:36:16Z","timestamp":1732962976000},"page":"35-39","source":"Crossref","is-referenced-by-count":0,"title":["COMPARISON OF DIFFERENT TREATMENT MODALITIES OF CHELATION THERAPY IN BETA THALASSEMIA MAJOR PATIENTS"],"prefix":"10.55519","volume":"36","author":[{"given":"Ghazal","family":"Usman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mahfooz ur Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifa","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Sarmad","family":"Hafeez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34325","published-online":{"date-parts":[[2024,2,5]]},"container-title":["Journal of Ayub Medical College Abbottabad"],"original-title":[],"link":[{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12436\/3679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12436\/3679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:46:50Z","timestamp":1733730410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/view\/12436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,5]]}},"URL":"https:\/\/doi.org\/10.55519\/jamc-01-12436","relation":{},"ISSN":["1819-2718","1025-9589"],"issn-type":[{"type":"electronic","value":"1819-2718"},{"type":"print","value":"1025-9589"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}