{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:25Z","timestamp":1791842905303,"version":"4.3.4"},"reference-count":0,"publisher":"Ayub Medical College, Abbottabad Pakistan","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ayub Med Coll Abbottabad"],"abstract":"<jats:p>Background: Peri orbital hyperpigmentation (POH) is a common presentation in dermatological outpatient departments and has multiple causes. Finding an appropriate treatment for POH can be challenging and requires case-based approach. The objective of this research was to study the effect of Biofiller Vs Platelet rich plasma meso-therapy in the treatment of Peri-orbital hyperpigmentation. Our hypothesis was Biofillers are better than platelet rich plasma therapy in the treatment of peri-orbital hyperpigmentation. It was a double-blinded randomized Control Trial (IRCT20230816059168N1) carried out in the Dermatology OPD of a tertiary care hospital in Rawalpindi over 4 months, i.e., 10.07.23 to 10.10.23. Methods: Forty-two patients meeting the inclusion criteria were included in the study after taking informed consent.\u00a0 Sampling was done by non-probability randomized sampling using the lottery method. 21 patients were treated with Bio fillers and another 21 by platelet rich plasma therapy (PRP). Sessions with a 2 weeks interval were done in each case and results were analyzed by peri-orbital photo-metric pigmentation scale and clinical grading improvement scale rated by a physician. Patient satisfaction and complications were also recorded.\u00a0Results: Statistically significant difference in results of Group A as compared to Group B, regarding improvement in photonumeric scale, evaluation of efficacy by a blinded dermatologist and patient satisfaction i.e. p= 0.001, 0.014 and 0.001 respectively. In group A, pain was reported by 3 (14.3%), bruising by 1 (4.76%) and lumps by 2(9.5%).\u00a0 PRP treated group had more side effects, i.e., 9 (42.8%) reported pain, 6 (28.6%) bruising and 4 (19%) more than one complaint (p-0.001). Conclusion: Biofillers are better than PRP in the treatment of POH.<\/jats:p>","DOI":"10.55519\/jamc-01-12585","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T10:36:16Z","timestamp":1732962976000},"page":"56-63","source":"Crossref","is-referenced-by-count":2,"title":["BIOFILLER VS PLATELET RICH PLASMA MESOTHERAPY IN THE TREATMENT OF PERI-ORBITAL HYPERPIGMENTATION IN PATIENTS PRESENTING TO OUTPATIENT DEPARTMENT OF DERMATOLOGY IN A TERTIARY CARE HOSPITAL-AN RCT"],"prefix":"10.55519","volume":"36","author":[{"given":"Sakina","family":"Sadiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Uzma Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ayesha Rizwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ayesha Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sibghatullah Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Shyna Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34325","published-online":{"date-parts":[[2024,2,5]]},"container-title":["Journal of Ayub Medical College Abbottabad"],"original-title":[],"link":[{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12585\/3683","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12585\/3683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:46:30Z","timestamp":1733730390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/view\/12585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,5]]}},"URL":"https:\/\/doi.org\/10.55519\/jamc-01-12585","relation":{},"ISSN":["1819-2718","1025-9589"],"issn-type":[{"value":"1819-2718","type":"electronic"},{"value":"1025-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}