{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T08:10:21Z","timestamp":1733731821447,"version":"3.30.1"},"reference-count":0,"publisher":"Ayub Medical College, Abbottabad Pakistan","issue":"3","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ayub Med Coll Abbottabad"],"abstract":"<jats:p>A 65-year-old male presented with complaints of weakness, lethargy, abdominal pain, and low-grade fever for the last few months. His examination revealed generalized lymphadenopathy and splenomegaly. A subsequent laboratory workup revealed atypical lymphoid cells with prominent double-bright positivity of CD19 and CD5 markers. Further investigations revealed deletion of the ATM (11q22.3) gene, and in accordance with other diagnostic factors, the patient was diagnosed with B-cell chronic lymphocytic leukaemia. Thus, treatment was initiated with oral chemotherapy followed by rituximab-bendamustine. After three weeks, he presented to the emergency room with a fever and worsening abdominal pain. On examination, massive splenomegaly was found. After stabilization, a bone marrow biopsy revealed findings which, in light of the clinical symptoms, were consistent with Richter's transformation of B-Cell chronic lymphocytic leukaemia into Diffuse large B-Cell Lymphoma<\/jats:p>","DOI":"10.55519\/jamc-03-11640","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T15:20:51Z","timestamp":1728141651000},"source":"Crossref","is-referenced-by-count":0,"title":["A BIZARRE PROGRESSION OF CHRONIC LYMPHOCYTIC LEUKAEMIA INTO DIFFUSE LARGE B-CELL LYMPHOMA"],"prefix":"10.55519","volume":"35","author":[{"family":"Danish Shakeel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hira","family":"Qadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mahad Mirza Baig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Shah Mureed Ojla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34325","published-online":{"date-parts":[[2023,7,10]]},"container-title":["Journal of Ayub Medical College Abbottabad"],"original-title":[],"link":[{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/11640\/3582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/11640\/3582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:51:36Z","timestamp":1733730696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/view\/11640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7,9]]}},"URL":"https:\/\/doi.org\/10.55519\/jamc-03-11640","relation":{},"ISSN":["1819-2718","1025-9589"],"issn-type":[{"type":"electronic","value":"1819-2718"},{"type":"print","value":"1025-9589"}],"subject":[],"published":{"date-parts":[[2023,7,10]]}}}