{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:12:54Z","timestamp":1778170374704,"version":"3.51.4"},"reference-count":0,"publisher":"Ayub Medical College, Abbottabad Pakistan","issue":"3","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ayub Med Coll Abbottabad"],"abstract":"<jats:p>Background: Type-1 diabetes mellitus (T1DM) and autoimmune thyroid disease can occur concomitantly and patients with TIDM have a high risk of other autoimmune conditions like thyroid disease and celiac disease. This study aimed to analyze the association of anti-GAD positive T1DM with anti-thyroid antibodies and celiac disease. Methods: This cross-sectional study was conducted at the Department of Paediatric Endocrinology &amp; Diabetes, National Institute of Child Health, Karachi Pakistan from July 2022 to December 2022. A total of 115 children of both genders aged between 1-18 years having known T1DM were analyzed. Children with chronic kidney disease or chronic liver disease were excluded. Those children were also not included whose parents\/caregivers did not wish their children to be part of this research. The blood sample of each child was taken in a sterilized container and sent to an institutional laboratory for biochemical investigations. Results: In a total of 115 patients, 67 (58.3%) were female and 48 (41.7%) males. The mean age was 8.87\u00b13.43 (ranging between 1.5-17 years). The mean HbA1c was 11.86\u00b17.31%. It was found that anti-GAD IgG was having signification association with celiac disease (p&lt;0.001). Significant correlation of anti-GAD positive antibodies with Ttg-IgG antibodies (correlation coefficient=0.303, p=0.001), thyroid peroxidase antibodies (correlation coefficient=0.228, p=0.001). Conclusion: High proportions of children with anti-GAD positive T1DM patients were found to have thyroid disorders and celiac disease. A significant correlation was found between anti-GAD positive antibodies, celiac disease and anti-thyroglobulin antibodies.<\/jats:p>","DOI":"10.55519\/jamc-03-12011","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T15:20:51Z","timestamp":1728141651000},"source":"Crossref","is-referenced-by-count":1,"title":["CELIAC AND AUTOIMMUNE THYROID DISEASE IN PATIENTS WITH ANTI-GAD POSITIVE TYPE-1 DIABETES MELLITUS"],"prefix":"10.55519","volume":"35","author":[{"family":"Versha Rani Rai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zubair Khoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Maira Riaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Roshia Parveen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Shazia Mahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mohsina Noor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34325","published-online":{"date-parts":[[2023,8,10]]},"container-title":["Journal of Ayub Medical College Abbottabad"],"original-title":[],"link":[{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12011\/3568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/download\/12011\/3568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:51:08Z","timestamp":1733730668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jamc.ayubmed.edu.pk\/jamc\/index.php\/jamc\/article\/view\/12011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7,9]]}},"URL":"https:\/\/doi.org\/10.55519\/jamc-03-12011","relation":{},"ISSN":["1819-2718","1025-9589"],"issn-type":[{"value":"1819-2718","type":"electronic"},{"value":"1025-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,10]]}}}