{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:53:14Z","timestamp":1771494794647,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>Five novel derivatives of N-(9,10-dihydro-9,10-dioxoanthracenyl)-1H-indole-2-carboxamide were synthesized and their lipid-lowering effects studied in hyperlipidemic rats. Fusion of the anthraquinone derivatives at high temperature with 5-indole-2-carbonyl chloride, followed by recrystallization from chloroform=methanol gave the desired compounds in excellent yields. Compounds 1 to 5 at a non-toxic dose (1 ml of 57 mM solutions) and bezafibrate as positive control were administered to rats that were hyperlipidemic due to treatment with Triton WR-1339. A decrease in the plasma levels of triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) and an increase in the plasma level of high-density lipoprotein-cholesterol (HDL-C) were observed with compounds 1, 3, 4, and 5. Compounds 1, 4, and 5 significantly reduced total cholesterol (TC) levels as well. These compounds may provide agents for targeting dyslipidemia and cardiovascular disease.<\/jats:p>","DOI":"10.5560\/znc.2012-0224","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T08:48:55Z","timestamp":1394700535000},"page":"21-28","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents"],"prefix":"10.1515","volume":"69","author":[{"given":"Manal","family":"Al-Najdawi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Hiari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Qirim","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Al-Zaytoonah Private University, Amman 11733, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan","family":"Shattat","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Al-Zaytoonah Private University, Amman 11733, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al-Zweri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan Abu","family":"Sheikha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Al-Zaytoonah Private University, Amman 11733, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/znc.2014.69.issue-1-2\/znc.2012-0224\/znc.2012-0224.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.5560\/znc.2012-0224\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.5560\/znc.2012-0224\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T16:29:45Z","timestamp":1624379385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.5560\/znc.2012-0224\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2014,2,1]]}},"alternative-id":["10.5560\/znc.2012-0224"],"URL":"https:\/\/doi.org\/10.5560\/znc.2012-0224","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}