{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:04Z","timestamp":1783322164822,"version":"3.54.6"},"reference-count":0,"publisher":"SEMES (Sociedad Espanola de Medicina de Urgencias y Emergencias)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emergencias"],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:p>Objetivo. La intoxicaci\u00f3n aguda por colchicina se asocia con una elevada mortalidad. La identificaci\u00f3n precoz de los\npacientes de alto riesgo es crucial para una intervenci\u00f3n oportuna. El valor pron\u00f3stico de la concentraci\u00f3n plasm\u00e1tica\nde colchicina (ColC) no ha sido estudiado. El objetivo fue desarrollar un nomograma para predecir la mortalidad intrahospitalaria en la intoxicaci\u00f3n aguda por colchicina utilizando la ColC al ingreso y el tiempo transcurrido desde la\ningesta.\nM\u00e9todos. Se realiz\u00f3 un estudio de cohorte retrospectivo, en dos centros (2000\u20132020). Se incluyeron pacientes con intoxicaci\u00f3n por colchicina procedentes de un servicio franc\u00e9s de cuidados cr\u00edticos toxicol\u00f3gicos y de un centro italiano de\ncontrol de intoxicaciones. Para la validaci\u00f3n se incluyeron datos del propio registro y de casos publicados en trabajos\nprevios. Se desarrollaron modelos de regresi\u00f3n log\u00edstica utilizando como variables la ColC al ingreso (ng\/mL), el tiempo\ndesde la ingesta hasta la determinaci\u00f3n de la ColC (h) y la mortalidad intrahospitalaria como variable de resultado.\nResultados. Se desarroll\u00f3 un nomograma a partir de datos de 52 pacientes (conjunto de entrenamiento), que fue validado en tres conjuntos de prueba independientes (n = 25, 13 y 16, respectivamente). En este estudio retrospectivo,\nel nomograma mostr\u00f3 potencial para discriminar a los pacientes con mayor riesgo.\nConclusiones. Se presenta un nomograma exploratorio para la estratificaci\u00f3n precoz del riesgo de muerte tras intoxicaci\u00f3n por colchicina. Su implementaci\u00f3n cl\u00ednica requiere una validaci\u00f3n prospectiva multic\u00e9ntrica con una potencia estad\u00edstica adecuada<\/jats:p>","DOI":"10.55633\/s3me\/086.2026","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:50:22Z","timestamp":1783320622000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute colchicine poisoning: prediction of in-hospital mortality at hospital admission using a nomogram. A bicenter retrospective cohort study"],"prefix":"10.55633","author":[{"given":"Azzurra","family":"Schicchi","sequence":"first","affiliation":[{"name":"Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto L","family":"Malovini","sequence":"additional","affiliation":[{"name":"Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Voicu","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care, Lariboisi\u00e8re Hospital, Par\u00eds, Francia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Papa","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Malissin","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care, Lariboisi\u00e8re Hospital, Par\u00eds, Francia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Deye","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care, Lariboisi\u00e8re Hospital, Par\u00eds, Francia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria M","family":"Petrolini","sequence":"additional","affiliation":[{"name":"Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lonati","sequence":"additional","affiliation":[{"name":"Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Labat","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Lariboisi\u00e8re Hospital, Paris, Francia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care, Lariboisi\u00e8re Hospital, Par\u00eds, Francia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33356","published-online":{"date-parts":[[2026,7,6]]},"container-title":["Emergencias"],"original-title":["Intoxicaci\u00f3n aguda por colchicina: predicci\u00f3n de la mortalidad al ingreso hospitalario mediante un nomograma en una cohorte retrospectiva bic\u00e9ntrica"],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:50:22Z","timestamp":1783320622000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaemergencias.org\/articulo\/intoxicacion-aguda-por-colchicina-prediccion-de-la-mortalidad-al-ingreso-hospitalario-mediante-un-nomograma-en-una-cohorte-retrospectiva-bicentrica\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.55633\/s3me\/086.2026","relation":{},"ISSN":["1137-6821","2386-5857"],"issn-type":[{"value":"1137-6821","type":"print"},{"value":"2386-5857","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}