{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:10:55Z","timestamp":1778163055235,"version":"3.51.4"},"reference-count":0,"publisher":"IPEDSS - Instituto de Pesquisa e Determinacao Social da Saude Ltda","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RCI"],"abstract":"<jats:p>HIV infection remains a chronic condition of high clinical relevance, even with the advances provided by antiretroviral therapy. In this context, micronutrient deficiencies have been associated with poorer immune response, disease progression, increased risk of clinical complications, and incomplete recovery of CD4+ T lymphocytes. This study aimed to analyze the available scientific evidence on the impact of micronutrient deficiencies on HIV progression and response to antiretroviral therapy. This is an integrative literature review with a systematized approach, based on studies indexed in recognized scientific databases, including systematic reviews, meta-analyses, randomized clinical trials, cohort studies, and observational studies. Twenty studies were selected addressing micronutrients such as vitamin A, vitamin B12, vitamin D, zinc, selenium, and multivitamins in people living with HIV. The findings indicated that vitamin A and vitamin B12 deficiencies were associated with clinical progression and mortality, while low vitamin D levels were related to virological failure and lower CD4+ recovery during antiretroviral therapy. Zinc was associated with immunological failure and gastrointestinal morbidity, and selenium showed a potential relationship with viral load, survival, and immune response. Although supplementation may provide benefits in specific contexts, especially among individuals with confirmed deficiency or nutritional vulnerability, the results remain heterogeneous and dependent on the micronutrient assessed, the population studied, baseline nutritional status, and use of antiretroviral therapy. It is concluded that micronutrient deficiencies may act as markers of severity and possible cofactors in HIV progression, and individualized nutritional assessment is recommended as a complementary strategy to clinical care.\n\nKeywords: hiv; micronutrients; antiretroviral therapy; nutritional status.<\/jats:p>","DOI":"10.55703\/27644006060120","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:17:09Z","timestamp":1778159829000},"source":"Crossref","is-referenced-by-count":0,"title":["DEFICI\u00caNCIAS DE MICRONUTRIENTES NO HIV: IMPACTO NA PROGRESS\u00c3O DA DOEN\u00c7A E NA RESPOSTA \u00c0 TERAPIA ANTIRRETROVIRAL"],"prefix":"10.55703","volume":"06","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-077X","authenticated-orcid":false,"given":"Lismeia Raimundo","family":"Soares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34673","published-online":{"date-parts":[[2026]]},"container-title":["Revista Cient\u00edfica Ipedss"],"original-title":["Micronutrient Deficiencies in HIV: Impact on Disease Progression and Response to Antiretroviral Therapy"],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:17:12Z","timestamp":1778159832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistacientificaipedss.com\/deficiencias-de-micronutrientes-no-hiv-impacto-na-progressao-da-doenca-e-na-resposta-a-terapia-antirretroviral"}},"subtitle":[],"editor":[{"name":"RCI - Revista Cient\u00edfica Ipedss","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.55703\/27644006060120","relation":{},"ISSN":["2764-4006"],"issn-type":[{"value":"2764-4006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}