{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:35Z","timestamp":1788603215392,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Background: Neuroendocrine neoplasms (NENs) comprise a wide-ranging group of abnormal neoplasms with atypical presentations, from primary localized disease to extensive metastasis, reaching the bone and brain. The NENs are divided into two major groups: neuroendocrine tumors (NETs), which are well-differentiated tumors of any grade, and neuroendocrine carcinomas (NECs), which are poorly differentiated, high-grade cancers with a high risk of morbidity and mortality. The challenge of diagnosing NENs early, particularly prior to metastasis, highlights the importance of further studying these diseases. We present a case of aggressive metastatic neuroendocrine carcinoma of a gastrointestinal\/pancreaticobiliary origin. Case Report: A 54-year-old male with a past medical history of hypertension and left total hip replacement presented with generalized weakness, dyspnea on exertion, decreased appetite, and fatigue. Initial laboratory findings noted a hemoglobin of 3.1 g\/dL and platelets of 9 x 109\/L. CT scan findings revealed a splenic infarct, lytic bone lesions, and small bilateral occipital hemorrhages. Bone marrow biopsy was consistent with metastatic, high-grade, poorly differentiated neuroendocrine carcinoma favoring a gastrointestinal\/pancreaticobiliary origin. The patient expired shortly after starting chemotherapy due to the extensive disease. Conclusion: Neuroendocrine neoplasms may be discovered late in their course with distant metastatic spread and thus have a poor prognosis. This case report and literature review describes the presentation of metastatic high-grade neuroendocrine carcinoma in a patient presenting to a community hospital, and reviews the current literature and guidelines on neuroendocrine carcinomas.<\/jats:p>","DOI":"10.55729\/2000-9666.1017","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T06:40:56Z","timestamp":1649140856000},"page":"83-88","source":"Crossref","is-referenced-by-count":0,"title":["Rare Case of High Grade Neuroendocrine Carcinoma Found on Bone Marrow Biopsy: A Case Report"],"prefix":"10.55729","volume":"12","author":[{"given":"Alexander","family":"Belkin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Velayati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yordan","family":"Jimenez-Perez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubin","family":"Tharayil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lidonnici","sequence":"additional","affiliation":[{"name":"Department of Anatomic & Clinical Pathology, Long Island Community Hospital, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Patel","sequence":"additional","affiliation":[{"name":"New York Cancer and Blood Specialists, Patchogue, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2022,2,17]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1017&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:05:33Z","timestamp":1788602733000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol12\/iss1\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1017","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]}}}