{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:22Z","timestamp":1788603202547,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Background: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile.\nHypothesis: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI).\nMethods: Data was collected by retrospective chart query. Severe CDI was defined as a white blood cell count of more than 15000 (x 109 cells\/L) or serum creatinine levels greater than 1.5 mg\/dl. To examine the association between the primary outcome (severe CDI) and BMI, the factors of age, gender, albumin level, ICU admission, antibiotic use within 3 months of admission, diabetes, and hypertension were also considered. Patients with chronic kidney disease, end-stage liver disease, pregnancy, inflammatory bowel disease, previous gastrointestinal surgeries, active malignancy, and immunosuppressed were excluded.\nResults: 219 patients were included in the final study. Of these 52.8% of patients had severe CDI, and 47.2% had non-severe CDI. Compared to normal-weight patients, risk of severe CDI was not influenced by being obese (OR = 1.26, p = 0.5119), overweight (OR = 1.65, p = 0.21), or underweight (OR = 1.05, p = 0.9383). Males had higher odds of having severe CDI when compared with females (OR = 1.76, 95% CI = 1.03 to 3.01, p = 0.0395). Albumin levels greater than 3.0 mg\/dL were associated with lower odds of having severe CDI (OR = 0.41, 95% CI = 0.27 to 0.62, p &lt; 0.0001).\nConclusion: BMI of an individual does not appear to be associated with the severity of CDI.<\/jats:p>","DOI":"10.55729\/2000-9666.1123","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T04:22:50Z","timestamp":1668054170000},"page":"43-50","source":"Crossref","is-referenced-by-count":4,"title":["Is increased BMI a risk factor for developing severe Clostridioides Difficile Infection? A retrospective study"],"prefix":"10.55729","volume":"12","author":[{"given":"Tulika","family":"Chatterjee","sequence":"first","affiliation":[{"name":"University of Illinois College of Medicine at Peoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Bansal","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine at Peoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Abuzar","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine at Peoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habiba","family":"Hussain","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine at Peoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology  Royal Wolverhampton Hospitals NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2022,11,9]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1123&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:03:24Z","timestamp":1788602604000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol12\/iss6\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11,9]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1123","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]}}}