{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:13Z","timestamp":1788603193363,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Takotsubo cardiomyopathy or stress cardiomyopathy is a condition characterized by acute and transient left ventricular systolic dysfunction in the absence of coronary heart disease, occurring after an acute emotional or physical stressful event. Cardiac dysfunction in these patients is suspected to be secondary to catecholamine induced cardiac myocyte injury via cyclic AMP-mediated calcium overload or due to endothelial dysfunction. Even though left ventricular dysfunction in takotsubo cardiomyopathy is transient, it can lead to acute complications. Left ventricular thrombus formation is a widely reported complication and has an incidence of around 5-14% in Takotsubo cardiomyopathy patients and can lead to thromboembolic events like stroke. We report a case of takotsubo cardiomyopathy with an apical LV thrombus, complicated by a large cardioembolic stroke. This case constitutes a clinical conundrum, as LV thrombus would warrant prompt initiation of anticoagulation, while the severe ischemic stroke would be a contraindication for immediate anticoagulation.<\/jats:p>","DOI":"10.55729\/2000-9666.1205","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T10:41:51Z","timestamp":1688035311000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardioembolic Stroke secondary to Massive Stress-Induced Apical Thrombosis: A Clinical Conundrum relating to Anticoagulation Initiation"],"prefix":"10.55729","volume":"13","author":[{"given":"Siva Naga S.","family":"Yarrarapu","sequence":"first","affiliation":[{"name":"Resident Physician, Department of Internal Medicine Monmouth Medical Center\/RWJBH Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Reading Hospital West Reading, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikramaditya Samala","family":"Venkata","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine Cheshire Medical Center\/Dartmouth Health,  Keene, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasree","family":"Ravilla","sequence":"additional","affiliation":[{"name":"Resident Physician, Department of Internal Medicine Monmouth Medical Center\/RWJBH Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Mohan","sequence":"additional","affiliation":[{"name":"Resident Physician, Department of Internal Medicine Monmouth Medical Center\/RWJBH Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Bhide","sequence":"additional","affiliation":[{"name":"Resident Physician, Department of Internal Medicine Monmouth Medical Center\/RWJBH Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Anwar","sequence":"additional","affiliation":[{"name":"Interventional Cardiologist Monmouth Medical Center\/RWJBH Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2023,6,28]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1205&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:01:21Z","timestamp":1788602481000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol13\/iss4\/23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,6,28]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1205","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]}}}