{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:13Z","timestamp":1788603193361,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Objective This investigation aimed to investigate differences between dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) patients treated with cardiac resynchronization therapy with defibrillator (CRT-D) for tachycardia therapy-related outcomes as well as mortality during follow-up of at least 1 year. Methods Seventy-eight patients with DCM (n=42) and ICM (n=36) with implantation or upgradation to CRT-D were included in this study and analyzed for incidence of non-sustained ventricular tachycardia (NSVT), non-sustained ventricular fibrillation (NSVF), defibrillator therapies, anti-tachycardia pacing (ATP), and mortality. Results DCM was the underlying etiology in 42 (53.84%) and ICM in 36 (46.15%). Time to first therapy was numerically longer in DCM than in ICM (9.5 \u00b1 2.4 vs. 7.1 \u00b1 3.2; P-value = 0.088). DCM patients had significantly higher therapy-free survival and mortality compared with ICM patients (OR(95%CI): 0.238(0.155 - 0.424); log-rank P = 0.017) and (OR(95%CI): 0.612(0.254 - 0.924); log-rank P = 0.029). ICM (HR(95%CI): 0.529(0.243 - 0.925); P-value = 0.014) CAD (HR(95%CI): 0.326 (0.122 - 0.691): P-value = 0.003), and NSVT (HR(95%CI): 0.703(0.513 - 0.849): P-value = 0.005) were demonstrated as independent predictors of the primary endpoint of appropriate therapy in CRT-D and ICM (HR(95%CI): 0.421(0.321 - 0.524); P-value = 0.037), chronic kidney disease (CKD; HR(95%CI): 0.289(0.198 - 0.380); P-value = 0.013), and CAD (HR(95%CI): 0.786(0.531 - 0.967); P-value = 0.003) were predictors of mortality. Conclusion The clinical course of ICM and DCM cohorts who were treated with CRT-D differs significantly during follow-up, with increased tachycardia therapy and increased incidence of mortality in ICM patients<\/jats:p>","DOI":"10.55729\/2000-9666.1268","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T03:12:49Z","timestamp":1699153969000},"source":"Crossref","is-referenced-by-count":0,"title":["Tachycardia therapy outcomes of ischemic versus nonischemic cardiomyopathy on cardiac resynchronization therapy: A propensity score-matched analysis"],"prefix":"10.55729","volume":"13","author":[{"given":"Jahanzeb","family":"Malik","sequence":"first","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Awais","sequence":"additional","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehzad","family":"Zaffar","sequence":"additional","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmat","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of electrophysiology, Armed Forces Institute of Cardiology\/National Institute of Heart Disease, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Mehmoodi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ibn e Seena Hospital, Kabul, Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2023,11,4]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1268&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:00:24Z","timestamp":1788602424000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol13\/iss6\/20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,4]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,11,4]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1268","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,4]]}}}