{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:00:52Z","timestamp":1791388852015,"version":"4.3.3"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Immune Checkpoint inhibitors (ICIs) such as nivolumab, pembrolizumab, and ipilimumab are monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4) or program death (PD)1 and its ligand PDL1. Agents targeting PD1, such as pembrolizumab, have shown widespread efficacy in the past and are also associated with a wide range of immune-related adverse events (irAEs), including endocrine toxicities. A 31-year-old female with a medical history significant for Stage IIb Breast cancer on chemo and immunotherapy (pembrolizumab) presented with nausea, vomiting, and generalized abdominal pain. Laboratory studies showed a blood glucose level of 356 mg\/dl, elevated Anion gap 18 meq\/L, beta-hydroxybutyrate 46mg\/d, and low C-peptide levels<\/jats:p>","DOI":"10.55729\/2000-9666.1270","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T03:12:41Z","timestamp":1699153961000},"source":"Crossref","is-referenced-by-count":2,"title":["When Hormones are Being Difficult: A Rare Case and the Literature Review of Pembrolizumab-Induced Polyendocrinopathy"],"prefix":"10.55729","volume":"13","author":[{"given":"Muhammad","family":"Tayyeb","sequence":"first","affiliation":[{"name":"Department of Medicine, Monmouth Medical Center, Long Branch, NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan M","family":"Khan","sequence":"additional","affiliation":[{"name":"Emergency Critical Care Center, Michigan Medicine, Ann Arbor, MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Monmouth Medical Center, Long Branch, NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trishala","family":"Meghal","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Monmouth Medical Center, Long Branch NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MD, FACP","given":"Doantrang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Medicine, Monmouth Medical Center, Long Branch, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2023,11,4]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1270&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:00:18Z","timestamp":1788602418000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol13\/iss6\/21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,4]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,11,4]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1270","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,4]]}}}