{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:05Z","timestamp":1788603185564,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Hyperlipidemia and its association with cardiovascular diseases have been significant public health concerns for many decades. Statins have long been the primary therapeutic option for lowering cholesterol levels and reducing cardiovascular mortality. However, a substantial number of patients either do not achieve optimal lipid goals with maximally tolerated statin doses or experience statin intolerance. In recent years, there have been remarkable developments in the field of hyperlipidemia management, leading to the approval of novel hypolipidemic drugs in North America and Europe. This article reviews the clinical development of bempedoic acid, a promising new drug, alone and in combination with ezetimibe, as an alternative approach to managing hyperlipidemia. The Phase I trials established the safety and tolerability of bempedoic acid, paving the way for further investigation in Phase II and Phase III trials. Multiple phase II studies evaluated the lipid-lowering efficacy of bempedoic acid as monotherapy or in combination with other hypolipidemic agents, showing significant improvements in lipid levels and inflammatory markers. The recently approved fixed drug combination of bempedoic acid and ezetimibe presents a viable option for patients who need additional LDL-C lowering alongside dietary modifications and maximally tolerated statin therapy.<\/jats:p>","DOI":"10.55729\/2000-9666.1313","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T03:12:43Z","timestamp":1709349163000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Bempedoic Acid in Patients with Hyperlipidemia and Non-Alcoholic Fatty Liver Disease"],"prefix":"10.55729","volume":"14","author":[{"given":"Sibtain","family":"Nisar","sequence":"first","affiliation":[{"name":"Department of Medicine, Lady Reading Hospital, Peshawar, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Quaid e Azam Medical College, Bahawalpur, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Talha","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Quaid e Azam Medical College, Bahawalpur, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Waqar","family":"Hanif","sequence":"additional","affiliation":[{"name":"Department of Medicine, Quaid e Azam Medical College, Bahawalpur, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Armed Forces Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Mehmoodi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ibn e Seena Hospital, Kabul, Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahanzeb","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cardiovascular Analytics Group, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2024,3,1]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1313&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:59:28Z","timestamp":1788602368000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol14\/iss2\/6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1313","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}