{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:11Z","timestamp":1788603191983,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Introduction: Diagnosing inflammatory bowel disease (IBD) is hindered by the invasive procedures required for accurate classification as Crohn\u2019s disease (CD) or ulcerative colitis (UC). As alternatives, non-invasive tests using anti-Saccharomyces cerevisiae antibodies (ASCA) and anti-neutrophil cytoplasmic antibodies (ANCA) have gained significance. This study evaluated ANCA and ASCA antibody frequencies in IBD and their role in disease characterization in a Moroccan population. Methods: Conducted at Marrakech\u2019s Mohammed VI University Hospital from 2014 to 2018, this cross-sectional study included patients with suggestive symptoms or confirmed IBD diagnosis based on clinical, endoscopic, and histological criteria. Immunological investigations detected p-ANCA, c-ANCA, and ASCA using immunofluorescence and immunodot assays. Results: Among 60 participants (mean age: 33.1\u00b111.75 years), the 20\u201330-year age group was most affected (31.67%). CD, UC, and indeterminate colitis (IC) were diagnosed in 46.67%, 45%, and 8.33% patients, respectively. Gastrointestinal symptoms were prevalent (98.3%), with ANCA+\/ASCA- profile in 41% of UC patients versus 11% in CD, and ANCA-\/ASCA+ profile exclusive to CD (50%). ANCA positivity was significantly associated with UC, rectal syndrome, and inflammatory syndrome, whereas ASCA positivity was significantly associated with CD and K\u00f6nig\u2019s syndrome (p<\/jats:p>","DOI":"10.55729\/2000-9666.1347","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T22:02:40Z","timestamp":1715292160000},"source":"Crossref","is-referenced-by-count":1,"title":["ANCA and ASCA Profiles in a Moroccan Population With Inflammatory Bowel Diseases"],"prefix":"10.55729","volume":"14","author":[{"given":"Ouadii","family":"Abakarim","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Klevor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahcen","family":"El Moumou","sequence":"additional","affiliation":[{"name":"Biotechnology, Environment and Health Team, Laboratory of Sciences of Health and Environment, High Institute of Nursing Professions and Health Techniques, ISPITS Agadir- Annex Tiznit, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Hazime","sequence":"additional","affiliation":[{"name":"B2S Research Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Brahim","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Center of Clinical Research, University Hospital Mohammed VI, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Oubaha","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital Mohammed VI, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Krati","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital Mohammed VI, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahim","family":"Admou","sequence":"additional","affiliation":[{"name":"B2S Research Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2024,5,7]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1347&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:58:55Z","timestamp":1788602335000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol14\/iss3\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,5,7]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1347","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]}}}