{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:12Z","timestamp":1788603192017,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Pembrolizumab is utilized in the treatment of multiple different malignancies, including non-small cell lung cancer, head and neck squamous cell carcinoma, melanoma, renal cell carcinoma, endometrial cancer, and more. Pembrolizumab is an immune checkpoint inhibitor that inhibits the programmed cell death-1 (PD-1) signaling pathway. Despite its benefits in treating multiple cancers, there are many reported adverse effects of Pembrolizumab affecting various organ systems; rarely it can cause acute interstitial nephritis (AIN). We present the case of a 79-year-old male with metastatic retroperitoneal squamous cell carcinoma who was found to have recurrent acute interstitial nephritis after pembrolizumab therapy.<\/jats:p>","DOI":"10.55729\/2000-9666.1362","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:12:45Z","timestamp":1719979965000},"source":"Crossref","is-referenced-by-count":0,"title":["A Recurring Theme: A Rare Case of Pembrolizumab-Induced Acute Interstitial Nephritis"],"prefix":"10.55729","volume":"14","author":[{"given":"Jonathan","family":"London","sequence":"first","affiliation":[{"name":"Internal Medicine Resident at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Bulancea","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inaas","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Oriuwa","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Bolotova","sequence":"additional","affiliation":[{"name":"Nephrologist at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubin","family":"Tharayil","sequence":"additional","affiliation":[{"name":"Internal Medicine Program Director at Long Island Community Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2024,7,2]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1362&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:58:12Z","timestamp":1788602292000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol14\/iss4\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1362","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]}}}