{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:22:31Z","timestamp":1792790551630,"version":"4.5.0"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Endocrinopathies following immunotherapy have infrequently been documented in the literature. Adrenal insufficiency is a rare consequence of pembrolizumab immunotherapy, with incidence reported to be between 0.98 and 1.3%. We present the case of a 34-year-old female with triple negative breast cancer on chemotherapy who presented with generalized weakness with tachycardia, tachypnea and hypotension unresponsive to fluids. Despite initial improvement with intravenous hydrocortisone and midodrine, the patient continued to be symptomatically hypotensive following discharge and required re-admission. AM cortisol level was found to be &lt; 0.5 ug\/dl and ACTH was<\/jats:p>","DOI":"10.55729\/2000-9666.1375","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:12:40Z","timestamp":1719979960000},"source":"Crossref","is-referenced-by-count":3,"title":["Immunotherapy induced adrenal insufficiency: an underdiagnosed cause of persistent hypotension in cancer"],"prefix":"10.55729","volume":"14","author":[{"given":"Nina","family":"H. Cheng","sequence":"first","affiliation":[{"name":"Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lee","sequence":"additional","affiliation":[{"name":"Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Balchander","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St. Luke\u2019s Hospital, Monroe, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Mimms","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Medicine, St. Luke\u2019s Hospital, Monroe, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2024,7,2]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1375&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:58:12Z","timestamp":1788602292000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol14\/iss4\/14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1375","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]}}}