{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:13:09Z","timestamp":1788603189149,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>This meta-analysis assesses the recent Food and Drug Administration (FDA)-approved antifungal, rezafungin, for treating candidemia and invasive candidiasis\u2014 both are significant health concerns with limited treatment options. Two randomized controlled trials comparing rezafungin to caspofungin were meta-analyzed, revealing no significant differences in global cure rates and 30-day all-cause mortality. While rezafungin's unique attributes, like a novel mechanism and once-weekly dosing, may enhance patient adherence, concerns arise about its clinical relevance given the substantial investment. The study emphasizes the need for ongoing research, post-marketing surveillance, and real-world data to determine rezafungin's true value in managing these life-threatening fungal infections. Despite FDA approval, further investigation is warranted for a comprehensive understanding of rezafungin's efficacy and safety.\nKeywords: Rezafungin; Candidemia; Invasive candidiasis; Meta-analysis; Antifungal therapy<\/jats:p>","DOI":"10.55729\/2000-9666.1391","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:01:22Z","timestamp":1726045282000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Game Changer or More of the Same? A Comparative Meta-Analysis of Rezafungin and Caspofungin in Treating Candidemia and Invasive Candidiasis"],"prefix":"10.55729","volume":"14","author":[{"given":"Zouina","family":"Sarfraz","sequence":"first","affiliation":[{"name":"Fatima Jinnah Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Nasir","sequence":"additional","affiliation":[{"name":"Nishtar Medical University, Multan, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Javad","sequence":"additional","affiliation":[{"name":"Al Nafees Medical College, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aden","family":"Khan","sequence":"additional","affiliation":[{"name":"Fatima Jinnah Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Shah","sequence":"additional","affiliation":[{"name":"Fatima Jinnah Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musfira","family":"Khalid","sequence":"additional","affiliation":[{"name":"Fatima Jinnah Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"The Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzna","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"King Edward Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Minhas","sequence":"additional","affiliation":[{"name":"Fatima Jinnah Medical University, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchal Atta","family":"Gondal","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2024,9,9]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1391&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:57:52Z","timestamp":1788602272000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol14\/iss5\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,9,9]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1391","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]}}}