{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:12:53Z","timestamp":1788603173894,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>BACKGROUND - The COVID-19 pandemic caused a major burden on the healthcare system. Since the beginning of the pandemic, the timing of intubation in patients with COVID-19 induced acute respiratory distress syndrome (ARDS) remained an area of debate. STUDY DESIGN AND METHODS - A single-center, retrospective cohort study of all adult patients (n=161) with COVID-19 admitted to the ICU with acute hypoxic respiratory failure were included. The group was divided into patients intubated after a trial of NIV (N=100) and patients intubated without a trial of NIV (N=61). The primary outcome was to compare the mortality rates between the two groups. RESULTS ICU mortality was higher in patients intubated after a trial of the NIV group compared to those without a trial of NIV (69 % vs 52%, p = 0.044). Patients initially treated with a trial of NIV had an odds ratio (OR) of 2.17 for mortality compared to those intubated without a trial of NIV (95% CI 1.04-4.54). ICU length of stay was higher in the intubation after a trial of the NIV group, 11.9 vs 7.7 days (p= 0.001). Patients intubated after a trial of NIV had a longer hospital Length of stay (LOS) (IRR 1.39, 95% CI 1.05- 1.85, p =0.022). However, the duration of mechanical ventilation was similar in the two groups. CONCLUSION In ARDS, a lung protective strategy with low TV has been proven to improve patient outcomes. The use of a trial of NIV prior to intubation is associated with an increase in mortality.<\/jats:p>","DOI":"10.55729\/2000-9666.1499","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:55:21Z","timestamp":1751878521000},"page":"14-20","source":"Crossref","is-referenced-by-count":0,"title":["THE ASSOCIATION OF NON-INVASIVE VENTILATION AND MORTALITY IN COVID-19 INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME"],"prefix":"10.55729","volume":"15","author":[{"given":"Chahat","family":"Puri","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care, University of Arizona, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Duddu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Greater Baltimore Medical Center, Towson, Maryland Department of Internal Medicine, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahib","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sinai Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Negrin","sequence":"additional","affiliation":[{"name":"Division of Information Technology, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Greenburg","sequence":"additional","affiliation":[{"name":"Division of Information Technology, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vitberg","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.","family":"Carr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Greater Baltimore Medical Center, Towson, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2025,7,3]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1499&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:55:20Z","timestamp":1788602120000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol15\/iss4\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7,3]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1499","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]}}}