{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:21:14Z","timestamp":1789759274288,"version":"4.0.1"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) agonist, is used in the treatment of type 2 diabetes mellitus by reducing insulin resistance. While peripheral edema and fluid retention are well-documented adverse effects, isolated pleural effusion in the absence of heart failure is rare. We present the fourth reported case of a woman in her 60s with type 2 diabetes who developed recurrent left-sided pleural effusion after the initiation and dose escalation of pioglitazone. The effusion resolved completely following discontinuation of the drug. This case underscores the importance of early recognition of drug-induced pleural effusion and timely cessation of the offending agent to prevent morbidity.<\/jats:p>","DOI":"10.55729\/2000-9666.1541","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:16:16Z","timestamp":1757762176000},"page":"94-98","source":"Crossref","is-referenced-by-count":3,"title":["UNVEILING AN UNCOMMON COMPLICATION:  PLEURAL EFFUSION SECONDARY TO PIOGLITAZONE USE"],"prefix":"10.55729","volume":"15","author":[{"given":"Ranjana","family":"Chimauriya","sequence":"first","affiliation":[{"name":"MedStar Health Georgetown University (Baltimore) Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinandan","family":"Chittal","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"DuMont","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher James","family":"Haas","sequence":"additional","affiliation":[{"name":"MedStar Health Georgetown University (Baltimore) Program"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2025,9,12]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scholarlycommons.gbmc.org\/cgi\/viewcontent.cgi?article=1541&amp;context=jchimp","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:54:24Z","timestamp":1788602064000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol15\/iss5\/20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,12]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1541","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]}}}