{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:12:47Z","timestamp":1788603167737,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a distinct subtype of mature T-cell non-Hodgkin lymphoma characterized by large, strongly positive CD30 lymphoid cells that lack expression and rearrangement of the ALK gene. Here, we present a unique case of ALK-negative ALCL in a 34-year-old male patient who presented with acute on chronic back pain. Initial emergent MRI spine demonstrated lytic changes of L3 and L4 with probable psoas fluid collection, with high suspicion for Pott\u2019s disease. However, subsequent work-up including a CT-guided bone biopsy revealed ALK-negative ALCL. \u00a0Patient underwent radiation to his lumbar spine and psoas muscle, with good radiographic response in those areas, however, further imaging with PET\/CT showed widespread metastatic disease. Considering the burden of his disease, the patient received chemotherapy with BV-CHP, and achieved good response to therapy notable on his repeat PET\/CT after his third cycle. Unfortunately, due to insurance coverage, patient transitioned his care to a different facility and no further information could be obtained. \u00a0This case highlights an infrequent and unique presentation of ALK-negative ALCL, where progressive lumbar back pain in a young individual without B symptoms or lymphadenopathy warranted additional diagnostic workup for malignancy without anchoring to common diagnoses.<\/jats:p>","DOI":"10.55729\/2000-9666.1589","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:12:45Z","timestamp":1773882765000},"page":"80-85","source":"Crossref","is-referenced-by-count":0,"title":["ALK-negative anaplastic large cell lymphoma presenting as back pain"],"prefix":"10.55729","volume":"16","author":[{"given":"Khalid","family":"Javed","sequence":"first","affiliation":[{"name":"University of Maryland Upper Chesapeake Medical Center Bel Air, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah Malak","family":"Bilalaga","sequence":"additional","affiliation":[{"name":"MedStar Health Georgetown University Internal Medicine Residency Program, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareema","family":"Adnan","sequence":"additional","affiliation":[{"name":"Ascension Saint Agnes Healthcare, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Vasireddy","sequence":"additional","affiliation":[{"name":"MedStar Health Georgetown University Internal Medicine Residency Program, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blackwood","sequence":"additional","affiliation":[{"name":"MedStar Health Harbor Hospital, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Haas","sequence":"additional","affiliation":[{"name":"MedStar Health Georgetown University Internal Medicine Residency Program, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2026,3,17]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:53:21Z","timestamp":1788602001000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol16\/iss2\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,17]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1589","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}