{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T10:12:54Z","timestamp":1788603174752,"version":"build-2803163510"},"reference-count":0,"publisher":"Greater Baltimore Medical Center","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"abstract":"<jats:p>In 1976, Donald Cockcroft and M. Henry Gault published\u00a0a formula that estimates creatinine clearance.\u00a0 This study involved only Caucasian males and was done prior to the development and standardization of the modern creatinine assays.\u00a0 With the major advances in medicine and nephrology that have occurred over the past half century, it seems almost inconceivable that we would still be using this formula as the standard for medication dosing, yet this is the clinical reality. \u00a0We explore the tension between guidelines that suggest using eGFR for medication dosing and the practical reality of our current system and the knowledge gaps that have led to continued reliance on this formula.<\/jats:p>","DOI":"10.55729\/2000-9666.1592","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:14:13Z","timestamp":1773882853000},"page":"7-10","source":"Crossref","is-referenced-by-count":0,"title":["Renal Function Equations and Medication dosing: The Daily Clinical Dilemma"],"prefix":"10.55729","volume":"16","author":[{"given":"Witt","family":"Durden","sequence":"first","affiliation":[{"name":"Assistant Professor of Medicine, West Virginia University\/Charleston Area Medical Center,  Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Anees","sequence":"additional","affiliation":[{"name":"Assistant Professor of Medicine, West Virginia University\/Charleston Area Medical Center Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Topf","sequence":"additional","affiliation":[{"name":"Assistant Clinical Professor of Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI 48309 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34701","published-online":{"date-parts":[[2026,3,17]]},"container-title":["Journal of Community Hospital Internal Medicine Perspectives"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:53:43Z","timestamp":1788602023000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.gbmc.org\/jchimp\/vol16\/iss2\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,17]]}},"URL":"https:\/\/doi.org\/10.55729\/2000-9666.1592","relation":{},"ISSN":["2000-9666"],"issn-type":[{"value":"2000-9666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}