{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:41:45Z","timestamp":1792683705768,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Beh\u00e7et's disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Beh\u00e7et's disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods: Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for an average follow-up period of 3.9 \u00b1 1.3 years. Results: Parenchymal NBD patients showed elevated CSF levels of NFL, HoxB3, and YKL-40 as compared to nonparenchymal patients. NBD patients showing an increase in modified Rankin score (mRS) values during follow-up had significantly higher CSF NFL levels. Patients with relatively lower CSF NFL levels (<\/jats:p>","DOI":"10.55730\/1300-0144.5432","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T04:12:23Z","timestamp":1660536743000},"page":"1266-1273","source":"Crossref","is-referenced-by-count":8,"title":["Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Beh\u00e7et's disease"],"prefix":"10.55730","volume":"52","author":[{"given":"ZERR\u0130N","family":"KARAASLAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EL\u0130F","family":"\u015eANLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6ZLEM T\u0130M\u0130RC\u0130","family":"KAHRAMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VUSLAT","family":"YILMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ECE","family":"AKBAYIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u0130ZEM","family":"KORAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEMA","family":"\u0130\u00c7\u00d6Z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TUNCAY","family":"G\u00dcND\u00dcZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CEM \u0130SMA\u0130L","family":"K\u00dc\u00c7\u00dcKAL\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MURAT","family":"K\u00dcRT\u00dcNC\u00dc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERDEM","family":"T\u00dcZ\u00dcN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2022,1,1]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:59:09Z","timestamp":1792681149000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol52\/iss4\/47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5432","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}