{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:30Z","timestamp":1792683630660,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>To investigate the roles of vascular endothelial growth inhibitor (VEGI) and hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) in the treatment of refractory interstitial cystitis\/bladder pain syndrome (IC\/BPS) with hyperbaric oxygen (HBO).Materials and methods: A total of 38 patients were included. They were assessed before and 6 months after HBO treatment. Three- day voiding diaries were recorded, and O\u2019leary-Sant scores, visual analog scale (VAS) scores, quality of life (QoL) scores, pelvic pain, and urgency\/frequency (PUF) scores were evaluated. Bladder capacity was assessed by cystoscopy. Bladder mucosa was collected for Western blot, qRT-PCR, and immunofluorescence staining to compare the expression of VEGI and HIF-1\u03b1 before and after treatment. Results: Compared with before treatment, patients showed significant improvements in 24-h voiding frequency (15.32 \u00b1 5.38 times), nocturia (3.71 \u00b1 1.80 times), O\u2019leary-Sant score (20.45 \u00b1 5.62 points), VAS score (41.76 \u00b1 17.88 points), QoL score (3.03 \u00b1 1.44 points), and PUF score (19.95 \u00b1 6.46 points) after treatment (p &lt; 0.05). There was no significant difference in bladder capacity before and after treatment (p \u2265 0.05). The expression levels of VEGI and HIF-1\u03b1 protein and mRNA were significantly decreased 6 months after treatment compared with before treatment. Immunofluorescence staining results showed that the double positive expression of VEGI and HIF-1\u03b1 protein in bladder tissue of IC\/BPS patients after HBO treatment quantitatively decreased significantly.Conclusion: This study identified a possible mechanism by whic decreased after HBO treatment due tohypoxia reversal, which improved symptoms in IC\/BPS patients.<\/jats:p>","DOI":"10.55730\/1300-0144.5762","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T09:38:36Z","timestamp":1708421916000},"page":"26-32","source":"Crossref","is-referenced-by-count":3,"title":["The potential mechanism of treating IC\/BPS with hyperbaric oxygen by reducing vascular endothelial growth inhibitor and hypoxia-inducible factor-1\u03b1"],"prefix":"10.55730","volume":"54","author":[{"given":"Jing","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"KANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,1,1]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:52:27Z","timestamp":1792680747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5762","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]}}}