{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:55Z","timestamp":1792683595422,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"4","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients, and the associations of these molecules and the phenotypes of UC.          Materials and methods: This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Scoring System (MCS) was used for patients' clinical and endoscopic features (MES). Truelove and Richard's method was applied to the histology activity index (HAI). The human VEGF (Cat.E0080Hu) and the human calprotectin (Cat.E4010Hu) kits were used for the enzyme-linked immunosorbent assay (ELISA) of sVEGF and SCP.Results: The median sVEGF and SCP levels were higher in the patients compared to healthy controls [2139 ng\/L (126\u20135783) vs 888 ng\/L (715\u20135270), p=0.002 and 932 ng\/L (99\u20132648) vs 80 ng\/L (56\u2013920), p&lt;0.001, respectively]. There was a strong correlation between the SCP and sVEGF values (rho=0.819, p&lt;0.001). The MCS, MES, and HAI values were positively correlated to sVEGF and SCP concentrations.Conclusion : Serum VEGF and SCP can be valuable auxiliary biomarkers for UC.<\/jats:p>","DOI":"10.55730\/1300-0144.5841","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:15:49Z","timestamp":1725336949000},"page":"718-726","source":"Crossref","is-referenced-by-count":0,"title":["Serum vascular endothelial growth factor has diagnostic and prognostic significiances in ulcerative colitis"],"prefix":"10.55730","volume":"54","author":[{"given":"MUSA","family":"SALMANO\u011eLU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130RFAN","family":"K\u00dc\u00c7\u00dcK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BA\u015eAK","family":"\u00c7AKIR G\u00dcNEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BET\u00dcL","family":"DO\u011eANTEK\u0130N","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NURG\u00dcL","family":"T\u00dcKEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZEL\u0130HA","family":"SER\u0130NDA\u011e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAB\u0130P","family":"YILMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MUSTAFA","family":"KAPLAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,8,23]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:50:48Z","timestamp":1792680648000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss4\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,23]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5841","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]}}}