{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:37Z","timestamp":1792683637601,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"4","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/ Aim: In the literature, almost all of the propounded nerve conduits for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to define a new nerve conduit model in a flap pattern and evaluate the effect of pedicled vascularized jejunal flap on nerve regeneration after wrapping around a sciatic nerve.Materials and Methods: A total of 90 Wistar albino rats were randomly divided into nine groups each with 10 rats. The first three groups constituted the control groups, whereas groups 4-6 were the jejunum conduit (JC) - applied groups. A mucosa resected JC (MRJC) was performed to groups 7-8. Epineurial neurorrhaphy was performed in groups 1, 4, and 7; repair with nerve graft was obtained in groups 2, 5, and 8; and a 1-cm long nerve defect was created in groups 3, 6, and 9. After 2 months of follow-up, nerve regeneration was assessed by statistical analyses of the sciatic functional index (SFI) and histopathological evaluation.Results:  The MRJC groups had significantly better results in terms of SFI (p \u2248 0.005). Statistical differences in axonal degeneration, axonal density, myelination and disorganization were found between all control subgroups and MRJC groups (p\u2248 0.022, p\u2248 0.001, p\u2248 0.001, and p\u2248 0.039, respectively).Conclusion: In this study, the feasibility of wrapping around the nerve repair zones of the pedicled autologous flaps designed in a tubular fashion has been observed in a small rat model and must be further validated in larger animals before clinical testing.<\/jats:p>","DOI":"10.55730\/1300-0144.5851","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:15:27Z","timestamp":1725336927000},"page":"792-803","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats"],"prefix":"10.55730","volume":"54","author":[{"given":"MAJ\u0130D","family":"ISMAYILZADE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u0130LSEV","family":"INCE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PEMBE","family":"OLTULU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u0130KRULLAH","family":"BAYCAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00dcN\u00dcR SEL\u00c7UK","family":"KEND\u0130R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET","family":"DADACI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,8,23]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:50:43Z","timestamp":1792680643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss4\/23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,23]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5851","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]}}}