{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:18Z","timestamp":1792683618828,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"5","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: The primary objective of this study was to demonstrate the commonalities and distinctions between patients with seronegative and seropositive primary Sj\u00f6gren's syndrome (pSS).Materials and methods: Between January 2010 and June 2023, 399 pSS were retrospectively examined. Patients with negative anti-SSA\/Ro, anti-SSB\/La, ANA, and RF antibodies comprised the seronegative group, while patients with at least one antibody positivity classified the seropositive group.Results: The most common clinical features were arthralgia (81.2%), arthritis (11.5%), hematological (19.8%) and pulmonary (11.8%) involvement. In 41 patients (10.3%), no autoantibody positivity was detected. The number of patients with at least one extraarticular involvement was statistically more frequent in the seropositive group (p=0.011). Dry mouth was found to be more prevalent among seronegative patients (p=0.003). While hyperimmune gammaglobulinemia exhibited a higher prevalence within the seropositive group (p=0.004), the occurrence of reduced complement levels demonstrated similar rates in both groups. All deaths that occurred were observed exclusively within the seropositive group (17\/358, 4.7%). No difference was observed between the two groups concerning mortality (p=0.237) and the malignancies (seropositive group:9\/358, 2.5% vs seronegative group:3\/41, 7.3%, p=0.115). There was a statistically significant association between low C4 levels (OR=2.99 [1.09-8.16], p=0.045 in Model 1, OR=3.10 [1.14-8.42], p=0.022 in Model 2), and extraarticular findings.Conclusion: In conclusion, while hematologic, renal, pulmonary, and neurological involvements are observed with similar frequency in both seronegative and seropositive pSS patients, the presence of any extra-articular manifestations was more common in seropositive patients. Additionally, there was a relationship between extra-articular involvement and low C4 levels.<\/jats:p>","DOI":"10.55730\/1300-0144.5873","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:14:31Z","timestamp":1729656871000},"page":"956-962","source":"Crossref","is-referenced-by-count":1,"title":["Are there differences in the clinical and laboratory features of patients with seronegative primary Sj\u00f6gren's syndrome?"],"prefix":"10.55730","volume":"54","author":[{"given":"M\u00dc\u00c7TEBA ENES","family":"YAYLA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAH\u0130ME","family":"AKSOY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM\u0130NE","family":"USLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZEHRA","family":"KARAMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RECEP","family":"YILMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHMET","family":"\u0130LBAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u0130LG\u00dcN","family":"G\u00d6VE\u00c7 GIYNA\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ABDULBAK\u0130","family":"GAYDAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHMET","family":"USTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YETER","family":"MAHMUTO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u015eKIN","family":"ATE\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MURAT","family":"TURGAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,10,18]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:50:01Z","timestamp":1792680601000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss5\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10,18]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5873","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}