{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:44:29Z","timestamp":1792590269203,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: This study aims to investigate the association between rs2267437, rs5751129 and rs132770 polymorphisms of the XRCC6 gene, which plays a role in repairing DNA double strand breaks, and the risk of Papillary Thyroid Cancer (PTC).Methods: The study included 150 patients who had been diagnosed with PTC and 204 healthy control subjects. Genotyping of SNPs was performed by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR - RFLP).Results: In rs2267437 polymorphism, individuals with GG genotype had lower risk of PTC than wild-type CC genotype (p=0.037, 95% CI=0.19-0.96, OR=0.67). The combined genotypes CG+GG were found to be related to a reduced risk of PTC compared to the wild-type CC (p=0.023, 95% CI=0.40-0.94, OR=0.61) in the recessive model (GC+GG vs. CC). In addition, a query of the Genotype-Tissue Expression (GTEx) database showed that the rs2267437 polymorphism may alter the expression level of XRCC6 in whole blood (p=0.0009) but not in thyroid tissue. There were no significant association of rs5751129 and rs132770 polymorphisms with PTC.Conclusion: In conclusion, this study demonstrated that rs2267437 polymorphism may have a protective effect against PTC in the Turkish population. However, rs5751129 and rs132770 polymorphisms were not associated with the disease.<\/jats:p>","DOI":"10.55730\/1300-0144.5902","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:54:18Z","timestamp":1733720058000},"page":"1215-1222","source":"Crossref","is-referenced-by-count":1,"title":["Association between papillary thyroid cancer and XRCC6 gene polymorphisms in the Turkish population"],"prefix":"10.55730","volume":"54","author":[{"given":"EGEMEN","family":"AKG\u00dcN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAD\u0130ME","family":"MUTLU \u0130\u00c7DUYGU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEMET","family":"\u015eENG\u00dcL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EBRU","family":"ALP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET","family":"ALKANAT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AYSEG\u00dcL","family":"CEB\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TUNCER","family":"OZTURK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,1,1]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:10:50Z","timestamp":1792588250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss6\/6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5902","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]}}}