{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:26:01Z","timestamp":1793784361468,"version":"4.6.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"6","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p&lt;0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p&lt;0.001), while cough and runny nose were significantly more common in AI (p&lt;0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p&lt;0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, \u226460 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP &lt;124.5 mg\/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.<\/jats:p>","DOI":"10.55730\/1300-0144.5905","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:54:02Z","timestamp":1733720042000},"page":"1237-1243","source":"Crossref","is-referenced-by-count":2,"title":["A new scoring in differential diagnosis: multisystem inflammatory syndrome or adenovirus infection?"],"prefix":"10.55730","volume":"54","author":[{"given":"MUSTAFA","family":"GEN\u00c7EL\u0130","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TALHA","family":"\u00dcST\u00dcNTA\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6ZGE","family":"AKCAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0130NAN","family":"SAYLIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAT\u0130H","family":"ERCAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEVG\u0130","family":"PEKCAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0130P\u0130L","family":"GEN\u00c7EL\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEVG\u0130","family":"DURMU\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MUSTAFA","family":"ARGUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,12,10]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:30:10Z","timestamp":1793781010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss6\/9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12,10]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5905","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]}}}