{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:46Z","timestamp":1792683586233,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who were treated with immunosuppressives.Materials and Methods: Twenty-three patients with biopsy-confirmed kidney sarcoidosis were included. Demographics, clinical, pathological, and laboratory findings, in addition to treatments, and outcomes of twenty patients with at least one month of follow-up were evaluated.Results: Median age at the time of biopsy was 47 years(60.9 % female). Median baseline eGFR and proteinuria were 21.5 ml\/min and 1 g\/g or g\/day, respectively. Nineteen of the 23 patients were diagnosed with non-glomerular disease (Four patients had glomerular diseases). Extrarenal sarcoidosis was present in 86.7% of patients. Granulomatous interstitial nephritis(56.5 %) and nephrosclerosis with intratubular calcific casts(17.4 %) were the two most common diagnoses. All patients initially received 1 mg\/kg\/day steroids for kidney involvement. Although no statistical difference was observed in kidney function during follow-up, steroids improved eGFR in the first month compared with baseline in patients with non-glomerular diseases(p=0.049). Eventually, 45 % of the patients developed end-stage-kidney-disease, and 45 % of cohort had a treatment response. Patients with higher baseline calcium levels(p=0.03) and lower degrees of interstitial fibrosis\/tubular atrophy(p=0.043) had better kidney outcomes. Moreover, none of the patients with sarcoidosis-related secondary glomerular disease had a treatment response(p=0.043).Conclusions: Hypercalcemia and lower IF\/TA rates might be associated with better outcomes in sarcoidosis-related kidney involvement under immunosuppressives. Also, late diagnosis, irregular follow-up, and glomerular disorders could be poor prognostic factors.<\/jats:p>","DOI":"10.55730\/1300-0144.5907","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:53:51Z","timestamp":1733720031000},"page":"1252-1264","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological features for the prediction of immunosuppressive treatment responses in sarcoidosis-related kidney involvement: a single-center retrospective study"],"prefix":"10.55730","volume":"54","author":[{"given":"AHMET BURAK","family":"D\u0130R\u0130M","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VAFA","family":"SULEYMANOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OZGE","family":"HURDOGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6ZG\u00dcR","family":"OTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AY\u015eE","family":"ARTAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAVAS","family":"OZTURK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YASEM\u0130N","family":"OZLUK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IS\u0130N","family":"K\u0130L\u0130CASLAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAL\u0130L","family":"YAZ\u0130C\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2024,1,1]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:49:17Z","timestamp":1792680557000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol54\/iss6\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5907","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]}}}