{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:06Z","timestamp":1792683606138,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aimCarotid artery is the majority artery for brain feeding. Carotid Bodies (CBs) are located in carotid bifurcation and regulate body fluid pH. We aimed to evaluate the changes in CB-related pH levels as a consequence of degeneration induced by the ligation of both Common Carotid Arteries (BCCAL).Materials and methodsWe included 23 adult male New Zealand rabbits. A control group (n= 5); a sham group (0.5 mL saline injected n=5) and the main study group (subjected to the BCCAL procedure, n = 13). We monitored and recorded pH levels, and cardiac rhythms before, during, and after the experiments at two-day intervals. The study lasted three weeks. Additionally, we quantified both healthy and degenerated neuron densities within the CBs.ResultsAcross all groups, initial pH levels were: control (7.42 \u00b1 0.039), sham (7.39 \u00b1 0.059), and study (7.35 \u00b1 0.12). Before euthanasia, pH levels adjusted to control (7.40 \u00b1 0.029), sham (7.42 \u00b1 0.041), and study (7.39 \u00b1 0.12). Degenerated neuron density of CB was measured as: control (11 \u00b1 4\/mm^3), sham (394 \u00b1 74\/mm^3), and study (1363 \u00b1 347\/mm^3). In addition, statistical analysis post-ligation revealed significant differences: control vs. sham (p&lt;0.001), sham vs. study (p&lt;0.0005), and control vs. study (p&lt;0.000001).ConclusionsIncreased degenerate neuron density in the CB can lead to a reduction in blood pH immediately following BCAAL due to acutely developed CB ischemia, and timely pH renormalized because vertebrobasilar reverse blood flow begins to CB blood supply and reversed CB neurodegeneration renormalizes blood pH.<\/jats:p>","DOI":"10.55730\/1300-0144.5961","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T11:41:53Z","timestamp":1740483713000},"page":"223-230","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between the density of degenerated neurons in the carotid body and changes in blood pH"],"prefix":"10.55730","volume":"55","author":[{"given":"HAKAN","family":"KINA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AYDIN S\u0130NAN","family":"APAYDIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2025,2,18]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:48:10Z","timestamp":1792680490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol55\/iss1\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,18]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5961","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}