{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:25:44Z","timestamp":1793784344289,"version":"4.6.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aimPeripheral nerve injuries (PNI) are debilitating disorders affecting predominantly the younger generation, often leading to significant disabilities. Current treatment strategies are inadequate in addressing the complex nature of these injuries. Peripheral nerve healing and functional recovery are crucial components of both pathophysiology and therapeutic approach. High fructose corn syrup (HFCS) is a frequently used sweetener in several beverages and foods. And it is associated with several metabolic disturbances including insulin resistance and may impair nerve healing. This study investigates the therapeutic role of ivermectin on nerve regeneration following sciatic nerve injury and evaluates motor and sensorial functions together with histopathological evaluation. Additionally, we aimed to compare nerve healing between animals that consume high-fructose and those that do not.Materials and methodsForty-eight male Swiss albino mice were randomly divided into six groups, first-half consuming HFCS-42 (11% v\/v) and the second-half regular tap-water for 8 weeks. On 28th day, sciatic nerve injury (SNI) was performed on all groups. Ivermectin (1 mg\/kg) or gabapentin (30 mg\/kg) treatments were administered to selected groups. Body weight, blood glucose, motor function (Rotarod, open field test) and thermal-mechanical sensorial functions were assessed weekly. Finally, insulin levels were measured, and histopathological samples were taken.Results8 weeks of HFCS impaired mechanical-thermal sensorial functions with histopathologically poor nerve repair. Ivermectin resulted in improved sensorial and faster motor function recovery in HFCS groups. Elevated plasma insulin levels-HOMA-IR values were diminished by ivermectin in HFCS groups. In ivermectin non-HFCS group, histopathology revealed accelerated healing and higher scores in total. Ivermectin also ameliorated mechanical sensation loss after SNI alongside with cold sensation.ConclusionIvermectin accelerated sensorial and motor nerve recovery resulting in faster nerve healing alongside improved insulin-resistance, suggesting it might serve as a potential foundation for developing a new treatment for nerve regeneration after injury.<\/jats:p>","DOI":"10.55730\/1300-0144.5971","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T11:41:06Z","timestamp":1740483666000},"page":"299-312","source":"Crossref","is-referenced-by-count":1,"title":["Impact of ivermectin on nerve regeneration following sciatic injury in mice: the consequences of dietary high fructose"],"prefix":"10.55730","volume":"55","author":[{"given":"EZG\u0130 DEN\u0130Z","family":"ARIKAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BARI\u015eCAN","family":"\u00c7\u0130MEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AY\u015eE ECE","family":"GEZEN YILMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EL\u0130F","family":"AKAYDIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BERKAY","family":"ALPAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEN\u0130Z EK\u0130N","family":"ERBA\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERBLINA","family":"NIKSHIQI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEVDA","family":"M\u00dcFT\u00dcO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YILDIRIM","family":"SARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2025,2,18]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:28:41Z","timestamp":1793780921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol55\/iss1\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,18]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5971","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}