{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:06Z","timestamp":1792683606172,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"2","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: This study aimed to explore the role of Mac-2 binding protein glycosylation isomer (M2BPGi) serum levels as a biomarker that could contribute to understanding organ involvement and the overall disease process in systemic sclerosis (SSc).\nMaterials and methods: The cross-sectional study examined 108 patients with SSc. Seventy-two people were included in the control group. Demographic and clinical characteristics of the patients, laboratory and radiological findings, pulmonary function tests and echocardiography results, and presence of pulmonary hypertension (PHT) based on echocardiographic evaluation were recorded. Venous blood samples of 5 mL were collected from individuals. Human M2BPGi levels in the samples were measured using a specific kit.\nResults: There was no significant difference between the M2BPGi levels in the patient (median = 4749.69 pg\/mL, mean = 5351.75 \u00b1 2483.97) and the control group (median = 4638.07, mean = 4611.86 \u00b1 1333.15) (p = 0.071). Considering pulmonary arterial pressure (PAP) status, the average M2BPGi level in the normal PAP group was 5898.15 \u00b1 2555.61 pg\/mL, while it was 4258.96 \u00b1 1973.08 pg\/mL in the increased PAP group. The difference between these groups was statistically significant (p: 0.021). Examining PHT status, the average M2BPGi level was 5942.01 \u00b1 2579.14 pg\/mL in the group without PHT, decreasing to 4264.44 \u00b1 1917.63 pg\/mL in the group with PHT. There is a significant relationship regarding PHT (p: 0.016).\nConclusion: This study explores the relationship between M2BPGi and systemic involvements in SSc. It demonstrates a significant relationship between M2BPGi and PAP and PHT, suggesting that M2BPGi might serve as a noninvasive biomarker for predicting both PAP and PHT.<\/jats:p>","DOI":"10.55730\/1300-0144.5984","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T09:42:46Z","timestamp":1745487766000},"page":"404-412","source":"Crossref","is-referenced-by-count":1,"title":["Can mac-2 binding protein glycosylation isomer serve as a biomarker for predicting pulmonary arterial pressure and pulmonary hypertension in systemic sclerosis?"],"prefix":"10.55730","volume":"55","author":[{"given":"RIDVAN","family":"MERCAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u0130LARA","family":"BULUT G\u00d6KTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SONAT PINAR","family":"KARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NESL\u0130HAN","family":"MEL\u0130K \u00dcZ\u00dcM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAVA\u015e","family":"G\u00dcZEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2025,4,17]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:47:43Z","timestamp":1792680463000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol55\/iss2\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,17]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.5984","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}