{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:00:24Z","timestamp":1793041224709,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"4","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the Systemic Immune-Inflammation Index (SII) and the Pan-Immune-Inflammation Value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, T\u00fcrkiye [University of Health Sciences D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Education and Research Hospital (January 1, 2015\u2013October 1, 2022) and Etlik City Hospital (October 1, 2022\u2013March 11, 2025)]. Demographic, clinical, and laboratory data, along with treatment details and outcomes (discharge or in-hospital death), were systematically recorded.\nResults: A total of 76 patients were included, of whom 92.1% were male, with a mean age of 49.0 \u00b1 12.4 years. During hospitalization, 48.6% (n = 37) died. Both SII and PIV values at admission were significantly higher in non-survivors (p &lt; 0.001 for SII; p = 0.031 for PIV). In multivariate Cox regression analysis, higher SII (HR: 2.44; 95% CI: 1.05\u20135.67; p = 0.034) and PIV (HR: 2.08; 95% CI: 1.05\u20134.13; p = 0.030) were independently associated with increased risk of mortality. Receiver Operating Characteristic (ROC) analysis showed an AUC of 0.750 (95% CI: 0.649\u20130.865) for SII, with an optimal cutoff of 665.6 (sensitivity: 50%, specificity: 46%), and an AUC of 0.640 (95% CI: 0.519\u20130.769) for PIV, with a cutoff of 512.5 (sensitivity: 53%, specificity: 47%).\nConclusion: SII and PIV measured at hospital admission may serve as useful prognostic markers for predicting in-hospital mortality in patients with acute MP.<\/jats:p>","DOI":"10.55730\/1300-0144.6050","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:26:58Z","timestamp":1756373218000},"page":"971-981","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic role of systemic immune-inflammation index and pan-immune-inflammation value in acute methanol poisoning"],"prefix":"10.55730","volume":"55","author":[{"given":"HAT\u0130CE","family":"\u015eAH\u0130N","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00dcLAY","family":"ULUSAL OKYAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FATMA","family":"AYERDEN EB\u0130N\u00c7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEVZ\u0130 CO\u015eKUN","family":"S\u00d6KMEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMRE","family":"YA\u015eAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00dcL\u015eEN","family":"AK\u00c7AY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET DEN\u0130Z","family":"AYLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2025,8,15]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:46:14Z","timestamp":1792680374000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol55\/iss4\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,15]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6050","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]}}}