{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:03Z","timestamp":1792683543287,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"5","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model.\nMaterials and methods:  Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg\/kg and 100 mg\/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured.\nResults: Group 4 showed significantly lower EF grades compared with Groups 1 and 2 (p &lt; 0.001), and reduced arachnoid invasion compared with Group 1 (p &lt; 0.05). Group 4 had the lowest hydroxyproline levels (1.19 \u00b1 0.05 \u03bcg\/mL), followed by Group 3 (1.48 \u00b1 0.16 \u03bcg\/mL), Group 2 (1.67 \u00b1 0.24 \u03bcg\/mL), and Group 1 (1.94 \u00b1 0.30 \u03bcg\/mL) (all p &lt; 0.001).\nConclusion: Hesperidin significantly reduced EF and collagen deposition in a dose-dependent manner, demonstrating its potential as a preventive agent for FBSS.<\/jats:p>","DOI":"10.55730\/1300-0144.6080","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:10:41Z","timestamp":1760778641000},"page":"1265-1274","source":"Crossref","is-referenced-by-count":1,"title":["Hesperidin efficacy of epidural fibrosis in a post laminectomy rat model: an experimental study"],"prefix":"10.55730","volume":"55","author":[{"given":"EMRAH","family":"KESK\u0130N","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET SEL\u0130M","family":"GEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2025,10,14]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:45:33Z","timestamp":1792680333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol55\/iss5\/21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,14]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6080","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]}}}