{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:32:55Z","timestamp":1793781175487,"version":"4.6.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Pregnancy outcomes in women with systemic sclerosis (SSc) were evaluated in a nationwide cohort study. The impact of the disease on pregnancy outcomes was further assessed by comparing outcomes before and after the diagnosis of systemic sclerosis.\nMaterials and methods: A retrospective, nationwide, multicenter study was conducted under the supervision of the Ministry of Health. A nationwide cohort was between 1 January 2018, and 31 October 2025, including female patients with at least two recorded ICD codes for SSc (M34 subcategories) at an interval of at least 1 month, who were identified as pregnant before (pre-SSc) or after SSc (post-SSc) based on ICD-10 codes (Z32, Z33, Z34, Z35). The initiation of data collection was set as 1 January 2018, because complete birth outcome records were available in the database from that date onward. Patients were categorized into pre-SSc and post-SSc groups according to the timing of pregnancy relative to the diagnosis of SSc.\nResults: Among 43,663 patients diagnosed with SSc, data from a total of 4914 pregnancies\/pregnancy outcomes were retrospectively examined. Abortion was more frequent in women with SSc (11.70% in the pre-SSc group [relative risk (RR) 1.64, 95% CI 1.33\u20132.03], and 10.64% in the post-SSc group [RR 1.48, 95% CI 1.11\u20131.96]). The risk of gestational diabetes was significantly increased in both groups, with a greater increase observed in the pre-SSc group (RR 6.66); similarly, hypertensive disorders of pregnancy were more frequent in the pre-SSc group (RR 8.03). Puerperal complications were observed in 2.54% of the pre-SSc group and 3.12% (n = 22) of the post-SSc group (RR 1.85 and 2.28, respectively, compared with healthy controls).\nConclusion: Our results suggest that women with SSc are at increased risk; however, successful pregnancies are possible under appropriate multidisciplinary care.<\/jats:p>","DOI":"10.55730\/1300-0144.6196","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:47:47Z","timestamp":1782298067000},"page":"624-631","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy outcomes in systemic sclerosis before and after diagnosis: a retrospective nationwide cohort study"],"prefix":"10.55730","volume":"56","author":[{"given":"ALPER","family":"DO\u011eANCI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SERDAR CAN","family":"G\u00dcVEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NURAY","family":"YILMAZ \u00c7AKMAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-0653","authenticated-orcid":true,"given":"RIFAT","family":"BOZKU\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-6454","authenticated-orcid":true,"given":"SAL\u0130H","family":"BA\u015eER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-4093","authenticated-orcid":true,"given":"EK\u0130N","family":"DO\u011eANCI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7529-9299","authenticated-orcid":true,"given":"NESL\u0130HAN","family":"\u00d6ZT\u00dcRK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-6198","authenticated-orcid":true,"given":"\u015eUAY\u0130P","family":"B\u0130R\u0130NC\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-2821","authenticated-orcid":true,"given":"NA\u0130M","family":"ATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,6,16]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:23:48Z","timestamp":1793780628000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol56\/iss3\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6196","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}