{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:38:13Z","timestamp":1792683493407,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Pulmonary regurgitation following tetralogy of Fallot repair is a common long-term complication requiring pulmonary valve replacement. Injectable bioprosthetic valves offer a less invasive alternative to conventional surgical replacement, but comparative data in pediatric populations remain limited. This study aimed to evaluate short-term and long-term clinical outcomes of injectable pulmonary valve replacement and conventional pulmonary valve replacement in pediatric patients with severe pulmonary regurgitation following tetralogy of Fallot repair.\nMaterials and methods: This retrospective study included 22 pediatric patients who underwent pulmonary valve replacement. Patients were divided into injectable (n = 9) and conventional (n = 13) groups based on anatomical criteria. Primary outcomes included early postoperative parameters and long-term valve function. The mean follow-up duration was 10.5 \u00b1 2.5 years.\nResults: Favorable early outcomes were noted in the injectable pulmonary valve replacement cohort, including shorter intensive care unit stay (16.8 \u00b1 6.2 vs. 37.0 \u00b1 23.4 h, p = 0.021), reduced mechanical ventilation duration (5.2 \u00b1 3.9 vs. 15.4 \u00b1 11.4 h, p = 0.019), decreased chest tube drainage (206.7 \u00b1 108.2 vs. 513.1 \u00b1 274.1 mL, p = 0.005), and shorter hospital stay (5.4 \u00b1 2.4 vs. 8.4 \u00b1 3.1 days, p = 0.026). Long-term outcomes indicated similar valve function and right ventricular remodeling in the two groups, with excellent freedom from reintervention (100%) during follow-up.\nConclusion: Injectable pulmonary valve replacement appears to be a safe alternative, offering favorable early outcomes and long-term valve performance comparable to conventional methods. However, clinical experience and precise patient selection remain critical for achieving optimal results.<\/jats:p>","DOI":"10.55730\/1300-0144.6211","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:46:30Z","timestamp":1782297990000},"page":"778-786","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation"],"prefix":"10.55730","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-3874","authenticated-orcid":true,"given":"SERCAN","family":"TAK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-2151","authenticated-orcid":true,"given":"MURAT","family":"KO\u00c7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-3209","authenticated-orcid":true,"given":"AL\u0130","family":"KUTSAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-3419","authenticated-orcid":true,"given":"VEHB\u0130","family":"DO\u011eAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,6,16]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:42:50Z","timestamp":1792680170000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol56\/iss3\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6211","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}