{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:32:53Z","timestamp":1793781173250,"version":"4.6.1"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Parenteral feeding is used in critically ill patients when enteral nutrition is inadequate or intolerable, and the gastrointestinal tract is not functioning properly. Lipid emulsions play a major role in parenteral nutrition because they supply necessary fatty acids and a high-calorie density. We investigated the effects of parenteral lipid emulsions on mesenteric perfusion, inflammation-induced oxidation, and organ damage in lipopolysaccharide-induced mice endotoxemia model.\nMaterials and methods: In septic mice, organ damage induced by lipopolysaccharide was assessed by histopathology and biochemical examination. Additionally, an ultrasonic blood flowmeter was used to measure the impact of lipid emulsions on mesenteric blood flow.\nResults: When compared to control animals, mesenteric blood flow was reduced by parenteral lipid emulsions containing fish oil, soybean oil, and olive oil; however, when compared to the lipopolysaccharide group, the decrease in mesenteric blood flow was avoided by fish oil therapy. Lipid emulsions could not hinder the increase in liver and spleen weight caused by lipopolysaccharide injection. In septic mice, fish oil reduced liver damage, whereas in control animals, specific dosages of olive and soybean oils resulted in histopathologically significant liver and spleen damage. Parenteral lipid emulsions have shown an organ-specific impact on compromised oxidative equilibrium.\nConclusion: Fish oil emulsions containing high omega-3 fatty acids abrogate the decrease in mesenteric blood flow and prevent liver damage in this experimental endotoxemia model.<\/jats:p>","DOI":"10.55730\/1300-0144.6224","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:45:16Z","timestamp":1782297916000},"page":"897-906","source":"Crossref","is-referenced-by-count":0,"title":["Omega-3\u2013rich fish oil lipid emulsions significantly prevent sepsis-driven mesenteric hypoperfusion and multi-organ injury in murine models"],"prefix":"10.55730","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-5241","authenticated-orcid":true,"given":"G\u00d6K\u015eEN","family":"\u00d6Z","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9546","authenticated-orcid":true,"given":"ES\u0130N","family":"\u00d6Z\u00c7ELEB\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AY\u015eE YE\u015e\u0130M","family":"G\u00d6\u00c7MEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-8745","authenticated-orcid":true,"given":"CENK","family":"S\u00dcKMENS\u00dcER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-561X","authenticated-orcid":true,"given":"SELMA","family":"YILDIRIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-9087","authenticated-orcid":true,"given":"ARZU","family":"TOPEL\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALPER BEKTA\u015e","family":"\u0130SK\u0130T","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,6,16]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:23:14Z","timestamp":1793780594000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol56\/iss3\/30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6224","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}