{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:38:07Z","timestamp":1792683487662,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Medical Sciences"],"abstract":"<jats:p>Background\/aim: Neuropathic pain management requires high patient adherence and complex dose-titration regimens, making the readability of patient information leaflets (PILs) a critical patient safety factor. This study aimed to compare the clinical content quality and linguistic readability of PILs for neuropathic pain medications between T\u00fcrkiye (T\u0130TCK) and the United States (DailyMed).\nMaterials and methods: A total of 11 pairs of innovator medications were analyzed. Clinical content was assessed using the 15-item Keystone Clinical Content Checklist (KCCC). Readability was assessed using the Ate\u015fman index for Turkish texts and the Flesch Reading Ease Score (FRES) for English texts. Information quality and reliability were evaluated using DISCERN, the Global Quality Score (GQS), and JAMA benchmarks.\nResults: T\u0130TCK leaflets exhibited significantly higher word counts (2652.27 \u00b1 591.6) and sentence counts (180.55 \u00b1 30.7) than the US group (564.09 \u00b1 75.71 and 28.18 \u00b1 4.48, respectively; p &lt; 0.001). While the Turkish group demonstrated superior clinical exhaustiveness (KCCC: 14.82 \u00b1 0.40 versus 11.91 \u00b1 1.22; p &lt; 0.001), both groups remained within the \u201cDifficult\/Academic\u201d readability category, with no significant difference between Ate\u015fman and FRES scores (p = 0.4056). Notably, the US group demonstrated significantly higher educational utility (GQS: 4.27 \u00b1 0.47 versus 3.27 \u00b1 0.47; p = 0.0049), despite its lower content volume.\nConclusion: The comparison of regulatory frameworks revealed a structural trade-off: while the T\u0130TCK model offered superior clinical exhaustiveness, the FDA model provided significantly higher educational utility. Despite these differing priorities, neither model provided a readability advantage, as both remained within the \u201cDifficult\u201d category for the target patient population. These findings suggest that the high information density of the Turkish model acts as a significant barrier to effective health communication.<\/jats:p>","DOI":"10.55730\/1300-0144.6341","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:27:41Z","timestamp":1787066861000},"page":"973-982","source":"Crossref","is-referenced-by-count":0,"title":["A comparative analysis of clinical quality and readability of neuropathic pain patient information leaflets: T\u00fcrkiye versus the United States"],"prefix":"10.55730","volume":"56","author":[{"given":"GONUL","family":"SARI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-7248","authenticated-orcid":true,"given":"ARGUN","family":"PIRE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,8,13]]},"container-title":["Turkish Journal of Medical Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:42:20Z","timestamp":1792680140000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/medical\/vol56\/iss4\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0144.6341","relation":{},"ISSN":["1300-0144"],"issn-type":[{"value":"1300-0144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}