{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:33:53Z","timestamp":1793010833938,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"2","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Biology"],"abstract":"<jats:p>Background\/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated\u00a0cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (\u03b1)-tubulin\u00a0is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to\u00a0investigate \u03b1-tubulin acetylation and related molecular mechanisms in SMA.\u00a0Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and quantitative microscopic analysis were performed to analyze \u03b1-tubulin acetylation and related\u00a0mechanisms.\u00a0Results: The acetylation level of \u03b1-tubulin was decreased in the Drosophila model and in SMA patient fibroblast cells but not in mouse\u00a0models. This decrease in acetylation is associated with upregulation of the major tubulin deacetylase, HDAC6, in patient cells compared with healthy controls. Microtubules play a role in the organization of the Golgi apparatus, and we demonstrated that increasing \u03b1-tubulin\u00a0acetylation by pharmacological inhibition of HDAC6 partially restored the fragmented morphology of the Golgi apparatus in SMA.\u00a0Conclusion: Our findings provide new insight into the molecular basis of SMA, indicating that cellular pathologies, including abnormal\u00a0Golgi morphology, are associated with microtubule dysregulations caused by altered \u03b1-tubulin posttranslational modifications and\u00a0regulatory proteins. Our findings support that microtubule perturbations are part of SMA pathology.<\/jats:p>","DOI":"10.55730\/1300-0152.2798","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:22Z","timestamp":1777374922000},"page":"158-169","source":"Crossref","is-referenced-by-count":0,"title":["Modulating microtubule stability via \u03b1-tubulin acetylation partially restores\u00a0Golgi fragmentation in spinal muscular atrophy"],"prefix":"10.55730","volume":"50","author":[{"given":"PEL\u0130N","family":"ZOBARO\u011eLU \u00d6ZER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEMET","family":"G\u00d6Z\u00dcB\u00d6Y\u00dcK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6ZGE","family":"\u00c7ET\u0130N","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIKO","family":"HENSEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00dcZ\u0130N","family":"EMECEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ADAM","family":"MALIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MELISSA","family":"BOWERMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"CLAUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAYAT","family":"ERDEM YURTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAMZE","family":"BORA AKO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,4,21]]},"container-title":["Turkish Journal of Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T09:51:57Z","timestamp":1793008317000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/biology\/vol50\/iss2\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,21]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0152.2798","relation":{},"ISSN":["1300-0152"],"issn-type":[{"value":"1300-0152","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}