{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:41:47Z","timestamp":1792590107899,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Chemistry"],"abstract":"<jats:p>In continuation of our interest in identifying new \u03b1-glucosidase inhibitors with potential to become antidiabetic drugs, this work focuses on the study of 4-(dimethylaminoalkyl)piperazine-1-carbodithioate derivatives as \u03b1-glucosidase inhibitors. The eight heterocyclic piperazine-dithiocarbamate complexes studied in this work contain a variety of substitutions on their benzene ring exhibiting potent, noncompetitive inhibition of \u03b1-glucosidase. Dithiocarbamate and piperazine moieties are important pharmacophores with promising therapeutic prospects featuring facilitated drug delivery due to their lipophilic nature in addition to their \u03b1-glucosidase inhibitory activity. Enzyme kinetics, molecular dynamics simulations, and docking studies revealed that the target compounds bind to a new allosteric site that is located near the active site of \u03b1-glucosidase. Majority of molecular interactions of the compounds with the enzyme are mediated by hydrophobic contacts in addition to a number of important polar interactions. The current work identifies a number of chemical groups in the compounds that are responsible for potent inhibition of \u03b1-glucosidase. Moreover, it also provides new insights into understanding \u03b1-glucosidase inhibition by dithiocarbamate and piperazine-containing compounds that can be promising for development of new antidiabetic drugs.<\/jats:p>","DOI":"10.55730\/1300-0527.3453","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T04:13:07Z","timestamp":1665029587000},"page":"1484-1492","source":"Crossref","is-referenced-by-count":7,"title":["The 4-(dimethylaminoalkyl)piperazine inhibitors of \u03b1-glucosidase: allosteric enzyme inhibition and identification of interacting chemical groups"],"prefix":"10.55730","volume":"46","author":[{"given":"USMAN","family":"GHANI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAJDA","family":"ASHRAF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZAHEER UL","family":"HAQ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZAFER ASIM","family":"KAPLANCIKLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAT\u0130H","family":"DEM\u0130RC\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUSUF","family":"\u00d6ZKAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIBTAIN","family":"AFZAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2022,1,1]]},"container-title":["Turkish Journal of Chemistry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:00:04Z","timestamp":1792587604000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/chem\/vol46\/iss5\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0527.3453","relation":{},"ISSN":["1300-0527"],"issn-type":[{"value":"1300-0527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}