{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:40:29Z","timestamp":1792590029149,"version":"4.5.0"},"reference-count":0,"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","issue":"2","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Chemistry"],"abstract":"<jats:p>Cyclization reactions are among the most important and widely used methods for synthesizing biologically active fused heterocyclic compounds. In the present study, pyrazolopyrazinone derivatives (10a\u2013i) were synthesized from N-propargylated pyrazoles via nucleophilic cyclization with hydrazine hydrate under a nitrogen atmosphere. Nuclear magnetic resonance (NMR) spectral analyses confirmed that ring closure proceeded in a manner consistent with the formation of a six-membered pyrazinone moiety. In addition, the pyrazolotriazepinone derivative 15c was synthesized using an alternative approach. In this method, substitution with chloroacetone was first carried out, followed by ring closure with hydrazine hydrate, affording a seven-membered triazepinone system. Comparison of the NMR spectra of the resulting compounds clearly revealed structural differences between the two systems.<\/jats:p>","DOI":"10.55730\/1300-0527.3790","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:32:16Z","timestamp":1777375936000},"page":"199-206","source":"Crossref","is-referenced-by-count":0,"title":["Nucleophilic cyclization of N-propargylated pyrazole-5-carboxylates: synthesis of pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives"],"prefix":"10.55730","volume":"50","author":[{"given":"MEL\u0130K FIRAT","family":"MENGE\u015e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MELTEM","family":"TAN UYGUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34691","published-online":{"date-parts":[[2026,4,21]]},"container-title":["Turkish Journal of Chemistry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:53:03Z","timestamp":1792587183000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.tubitak.gov.tr\/chem\/vol50\/iss2\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,21]]}},"URL":"https:\/\/doi.org\/10.55730\/1300-0527.3790","relation":{},"ISSN":["1300-0527"],"issn-type":[{"value":"1300-0527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}