{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:03:22Z","timestamp":1767006202529,"version":"3.48.0"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"3-4","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Myosin VI (MVI) is a unique unconventional myosin which, unlike other myosins, moves towards the minus end of actin filaments. It is involved in numerous cellular processes such as endocytosis and trafficking, cell migration and adhesion, and gene transcription. It is widely expressed in all tissues, including the brain. Its lack in adult murine brains is associated with gliosis and impairment of neuronal transmission. Here, we demonstrate that the MVI level in the total mouse brain and its regions (cerebral cortex, cerebellum, and hippocampus) increases with the animal\u2019s age (from newborn up to 12\u2011month\u2011old mice). Its lack leads to enlargement of the brain and its examined areas, and an increase of the level of GFAP, the marker of glia cells, in adult mice. The data indicate an involvement of MVI in the brain maturation and possibly in development of an age\u2011dependent gliosis.<\/jats:p>","DOI":"10.55782\/1zwmve34","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T13:15:26Z","timestamp":1766841326000},"page":"176-186","source":"Crossref","is-referenced-by-count":0,"title":["Lack of unconventional myosin VI is associated with brain enlargement and gliosis progressing with age"],"prefix":"10.55782","volume":"85","author":[{"given":"Jolanta","family":"Nowak","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Karolczak","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland; Division of Neuropathology, Department of Pathology and Molecular Pathology, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria and Clinical Research Institute for Neurosciences, Johannes Kepler University, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Bilski","sequence":"additional","affiliation":[{"name":"Laboratory of Electron Microscopy, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Weis","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology and Molecular Pathology, Neuromed Campus, Kepler University Hospital, Johannes Kepler University, Linz, Austria and Clinical Research Institute for Neurosciences, Johannes Kepler University, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jolanta","family":"R\u0119dowicz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2025,12,27]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2758\/2539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2758\/2539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:58:40Z","timestamp":1767005920000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,27]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2025,12,29]]}},"URL":"https:\/\/doi.org\/10.55782\/1zwmve34","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"type":"electronic","value":"1689-0035"},{"type":"print","value":"0065-1400"}],"subject":[],"published":{"date-parts":[[2025,12,27]]}}}