{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:19Z","timestamp":1788820519468,"version":"build-2803163510"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"3-4","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Interhemispheric communication is a fundamental feature of the mammalian brain, supporting the bilateral integration of sensory, motor, cognitive, and emotional processes. While the corpus callosum has long been recognized as the principal commissural pathway, recent advances have illuminated a far more complex molecular and circuit\u2011level architecture. This\u00a0review synthesizes evidence from neuroanatomy, electrophysiology, molecular neuroscience, and neuroimaging to outline how interhemispheric signaling is organized and dynamically regulated. Fast excitatory and inhibitory neurotransmission provides the scaffold for callosal transfer, while neuromodulatory systems, including dopaminergic, cholinergic, serotonergic, and noradrenergic pathways, introduce a chemical layer of regulation that tunes excitability, synchrony, and hemispheric dominance. Developmental processes involving axon guidance molecules and neurotrophins shape the establishment of commissural networks, whereas activity\u2011dependent plasticity refines functional architecture of these networks across the lifespan. Importantly, interhemispheric interactions are not static but fluctuate dynamically according to behavioral demands, as demonstrated by recent models of dynamic laterality. Disruption of these lateralized processes is implicated in a broad spectrum of conditions, including stroke, dyslexia, autism spectrum disorder, schizophrenia, and mood disorders. By bridging cellular, molecular, and systems\u2011level insights, this review highlights interhemispheric communication as a key organizing principle of brain function and a promising target for therapeutic interventions aimed at restoring interhemispheric balance.<\/jats:p>","DOI":"10.55782\/85vnmg24","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T13:17:37Z","timestamp":1766927857000},"page":"196-260","source":"Crossref","is-referenced-by-count":2,"title":["Molecular and circuit mechanisms underlying interhemispheric communication in the mammalian brain"],"prefix":"10.55782","volume":"85","author":[{"given":"Jan","family":"Jab\u0142onka","sequence":"first","affiliation":[{"name":"Department of Animal Physiology, Institute of Experimental Zoology, Faculty of Biology, University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sztencel","sequence":"additional","affiliation":[{"name":"Museum and Institute of Zoology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Ruci\u0144ska","sequence":"additional","affiliation":[{"name":"Neuro\u2011My Neuropsychological Practice, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kolas","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Institute of Experimental Zoology, Faculty of Biology, University of Warsaw, Warsaw, Poland; Interdisciplinary Doctoral School, University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"34635","published-online":{"date-parts":[[2025,12,28]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2749\/2542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2749\/2542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:58:54Z","timestamp":1767005934000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,28]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2025,12,29]]}},"URL":"https:\/\/doi.org\/10.55782\/85vnmg24","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,28]]}}}