{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:54:09Z","timestamp":1760205249831},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2003,9,30]],"date-time":"2003-09-30T00:00:00Z","timestamp":1064880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Multiple efforts has underlined importance of calcium dependent cellular processes in the biochemical characterisation of Alzheimer's disease (AD), suggesting that abnormalities in calcium (Ca2+) homeostasis might be involved in the pathophysiology of the disease. Studies of the pathogenic mutations in presenilins 1 and 2 (PS1 and PS2) and amyloid precursor protein (APP) responsible for early onset familial AD have estabilished central roles for perturbed cellular Ca2+ homeostasis. Studies of apolipoprotein E (ApoE) neurotoxic effects in AD confirmed involvement of Ca2+-mediated mechanisms. Futher consequences of Ca2+ alterations in AD underline the importance of the ER and mitochondria as the regulatory sites involved in the pathogenesis of neuronal degeneration. Alterations of Ca2+ homeostasis include cells from peripheral tissues, including lymphocytes and fibroblasts from AD donors.<\/jats:p>","DOI":"10.55782\/ane-2003-1465","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T16:36:19Z","timestamp":1702053379000},"page":"171-183","source":"Crossref","is-referenced-by-count":37,"title":["Dysregulation of calcium in Alzheimer's disease"],"prefix":"10.55782","volume":"63","author":[{"given":"Maria","family":"Brzyska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danek","family":"Elbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2003,9,30]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/1465\/1465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/1465\/1465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T16:36:20Z","timestamp":1702053380000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/1465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,9,30]]}},"URL":"https:\/\/doi.org\/10.55782\/ane-2003-1465","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9,30]]}}}