{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T11:10:53Z","timestamp":1691147453569},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol Exp (Wars)"],"abstract":"<jats:p>This study was designed to investigate the involvement of opioidergic\/nitrergic systems in the anticonvulsant effect of mefloquine,\ncompared with chloroquine, in mice. Seizures were induced by pentylenetetrazol and maximal electroshock. Mice were randomly\nsubjected to receive mefloquine or chloroquine thirty minutes in advance. The role of opioidergic\/nitrergic systems was shown\nby co\u2011administration of pharmacological intervention and nitrite levels measurement in mice hippocampi. Results indicated\nthat mefloquine (40 mg\/kg) and chloroquine (5 mg\/kg) significantly decreased the occurrence of tonic hindlimb extension. Also,\nmefloquine 120 mg\/kg and chloroquine 5 mg\/kg significantly increased seizure latency and decreased mortality rate. Mefloquine\ndecreased seizure frequency too. Besides, mefloquine (20 mg\/kg) and chloroquine (5, 10 mg\/kg) significantly increased seizure\nthreshold. Interestingly, L\u2011NAME, 7\u2011NI and naltrexone pre\u2011treatment reversed the anticonvulsant effects of both mefloquine\n(20 mg\/kg) and chloroquine (5 mg\/kg). Moreover, co\u2011administration of minimal\u2011effective doses of morphine with mefloquine\/\nchloroquine (both 1 mg\/kg) potentiated anticonvulsant effects, which was reversed by naltrexone and endorsed the involvement\nof opioid receptors. Also, nitrite levels in mice hippocampi remarkably increased after treatment with both mefloquine (20 mg\/kg)\nand chloroquine (5 mg\/kg). To conclude, mefloquine could protect the central nervous system against seizures in PTZ\/MES\u2011induced\nmodels through opioidergic\/nitrergic pathways, with similarity to chloroquine effects.<\/jats:p>","DOI":"10.55782\/ane-2022-014","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T13:37:20Z","timestamp":1657805840000},"source":"Crossref","is-referenced-by-count":0,"title":["Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice"],"prefix":"10.55782","author":[{"given":"Saina Saadat","family":"Boroujeni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahabaddin","family":"Solaimanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh Mohammad","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Sabzevari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Shafaroodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeleh","family":"Maleki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parsa","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2022,6,30]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/pdf\/WRknZGfEVHAyhsvz.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/pdf\/WRknZGfEVHAyhsvz.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:45:38Z","timestamp":1691145938000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.55782\/ane-2022-014","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}