{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:40:31Z","timestamp":1716291631672},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Neurodegenerative disorders (NDD) are chronic neurological diseases characterized by loss and\/or damage to neurons along with the myelin sheath, and patients are at higher risk of severe infection with the SARS\u2011CoV\u20112. A comprehensive literature search was performed using relevant terms and inclusion\u2011exclusion criteria. Recent articles, subjects older than 50 years, and articles written in the English language were included, whereas letters to the editor and articles related to pregnant women were excluded from the review study. COVID\u201119 appears to damage angiotensin\u2011II receptors which cause natural killer cells to lose the ability to clear virus\u2011infected cells, owing to worse outcomes in patients with NDD. COVID\u201119 can worsen the symptoms of Alzheimer\u2019s disease. In addition, COVID\u201119 worsens drug\u2011responsive motor symptoms in Parkinson\u2019s disease (PD) and other symptoms like fatigue and urinary complaints. Vitamin D is essential in decreasing pro\u2011inflammatory and increasing anti\u2011inflammatory cytokines in ongoing COVID\u201119 infections and reducing angiotensin receptors and, hence, decreasing COVID\u201119 infection severity. Telemedicine shows promise for patients with NDD but is yet to overcome legal issues and personal barriers. COVID\u201119 has a significant effect on neurodegenerative conditions, which appears partly to the nature of the NDD and the neuro\u2011invasive capabilities of the SARS\u2011CoV\u20112. The protective role of vitamin D in patients with NDD further supports this hypothesis. Modifications in current health care, like the telemedicine platform, are required to address the increased risk of serious infection in this population. Further studies will be required to clarify conflicting reports in many fields.<\/jats:p>","DOI":"10.55782\/ane-2022-040","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T12:36:45Z","timestamp":1675427805000},"page":"424-432","source":"Crossref","is-referenced-by-count":0,"title":["Impact of COVID\u201119 infection in patients with neurodegenerative diseases with particular focus on Alzheimer\u2019s and Parkinson\u2019s disease"],"prefix":"10.55782","volume":"82","author":[{"given":"Prathima","family":"Guntipalli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirisha","family":"Gara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujan","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Hans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Abdullah","family":"Usman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeksha","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya","family":"Pakala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangam","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangharsha","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudarshan","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kester J.","family":"Nedd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2023,3,31]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2366\/2358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2366\/2358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:05:07Z","timestamp":1716289507000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,31]]}},"URL":"https:\/\/doi.org\/10.55782\/ane-2022-040","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,31]]}}}