{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:17:02Z","timestamp":1778919422628,"version":"3.51.4"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"2","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>The effect of nicotine on both anxiety and depression has been broadly studied. Moreover, citalopram and citicoline play a role in the modulation of anxiety and depression. This study was designed to examine the effects of nicotine on the antidepressant and anxiolytic responses induced by citalopram and citicoline in mice. Anxiety\u2011 and depression\u2011related behaviors were assessed with the elevated plus maze and forced swim test, respectively. The results showed that subcutaneous administration of nicotine decreased open\u2011arm time (OAT) and open\u2011arm entries (OAE) but increased immobility time, suggesting anxiogenic\u2011like and depressive\u2011like effects. Intraperitoneal administration of citalopram increased OAT but decreased immobility time, indicating that citalopram induced anxiolytic\u2011like and antidepressant\u2011like responses. Additionally, an injection of citicoline increased OAE but decreased immobility time, revealing anxiolytic\u2011like and antidepressant\u2011like effects. Interestingly, the subthreshold dose of nicotine potentiated the citalopram and citicoline effects on OAT and immobility time, which revealed anxiolytic\u2011like and antidepressant\u2011like behaviors. Locomotor activity was not significantly changed by any doses of the drugs. In conclusion, these findings suggest that interactions between nicotine and citalopram or citicoline occur upon induction of anxiolytic and antidepressant responses in mice.<\/jats:p>","DOI":"10.55782\/ane-2023-017","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T13:46:47Z","timestamp":1689342407000},"page":"194-202","source":"Crossref","is-referenced-by-count":3,"title":["The effect of nicotine on antidepressant and anxiolytic responses induced by citalopram and citicoline in mice"],"prefix":"10.55782","volume":"83","author":[{"given":"Fatemeh","family":"Khakpai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad\u2011Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2023,7,25]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2391\/2382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2391\/2382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:08:47Z","timestamp":1716289727000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,25]]}},"URL":"https:\/\/doi.org\/10.55782\/ane-2023-017","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,25]]}}}