{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T04:07:56Z","timestamp":1748837276022},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"2","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Cannabinoid and serotonin systems regulate many biological processes. The aim of the present study was to investigate the functional interaction between the cannabinoid and serotonergic systems of the primary somatosensory region (S1) of the brain in epileptiform activity caused by penicillin. The ACEA (an agonist of CB1 receptor), AM\u2011251 (an antagonist of CB1 receptor), 8\u2011OH\u2011DPAT (an agonist of 5\u2011HT1A receptor) and WAY\u2011100635 (an antagonist of 5\u2011HT1A receptor) were administered into the S1 after the same site administration of penicillin in urethane\u2011anesthetized rats. Electrocorticographic recording was done for a 90\u2011min period. The spike waves number and amplitude were recorded in 15\u2011min intervals. Areas under the curve (AUC) of the above\u2011mentioned spike alterations was calculated in 90 min. Spike waves with frequency of 30\/min and amplitude of 1.3 mV were appeared after penicillin microinjection. The ACEA (50 ng), 8\u2011OH\u2011DPAT (500 ng) and ACEA (10 ng) plus 8\u2011OH\u2011DPAT (100 ng) reduced epileptiform activity. The AM\u2011251 (50 ng) and WAY\u2011100365 (500 ng) prevented the reducing effects of ACEA (50 ng) and 8\u2011OH\u2011DPAT (500 ng). The AM\u2011251 alone increased spike waves frequency. The AUC results supported the effects of the above\u2011mentioned treatments. The results showed that activating CB1 and 5\u2011HT1A receptors in the S1 may reduce the epileptiform activity caused by penicillin. Therefore, alone and together activation of central CB1 and 5\u2011HT1A receptors might be considered in the management of epilepsy treatment.<\/jats:p>","DOI":"10.55782\/ane-2024-2420","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T10:41:12Z","timestamp":1727692872000},"page":"180-190","source":"Crossref","is-referenced-by-count":1,"title":["Primary somatosensory cortex CB1 and 5\u2011HT1A receptors interaction in the penicillin model of epilepsy"],"prefix":"10.55782","volume":"84","author":[{"given":"Amir","family":"Erfanparast","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Tamaddonfard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parastoo","family":"Jafarzadeh\u2011Balagafsheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmaeal","family":"Tamaddonfard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2024,6,28]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2420\/2461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2420\/2461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T10:41:13Z","timestamp":1727692873000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.55782\/ane-2024-2420","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}