{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:08:53Z","timestamp":1772014133784,"version":"3.50.1"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Neuropathic pain is a condition that results from nerve injury. There is a relationship between neuropathic pain and mood disorders. Citicoline, when used as a dietary supplement, exhibits neuroprotective, antidepressant, and anxiolytic properties. Moreover, bupropion is an atypical antidepressant with unique pharmacologic properties. We sought to investigate the effects of citicoline and bupropion as well as their possible interaction on the control of anxiety\u2011 and depression\u2011like behaviors in nerve\u2011ligated mice. Unilateral sciatic nerve ligation was performed on the right hind limb. Anxiety\u2011 and depression\u2011like behaviors were measured using the elevated plus\u2011maze and the tail suspension test, respectively. The results showed that sciatic nerve ligation decreased the percentage of time spent in the open arms of the elevated plus\u2011maze and increased the immobility time in the tail suspension test, displaying anxiogenic\u2011 and depressant\u2011like responses in the nerve\u2011ligated mice. Intraperitoneal administration of citicoline increased the percentage of time spent in the open arms and diminished the immobility time of the tail suspension test compared to the saline group, showing anxiolytic and antidepressant\u2011like responses. Additionally, the injection of bupropion induced antianxiety\u2011 and antidepressant\u2011like responses increasing the percentage of time spent in the open arms and reducing immobility time in nerve\u2011ligated mice. Co\u2011injection of bupropion and citicoline potentiated the antidepressant property of bupropion in nerve\u2011ligated mice. Additionally, we determined an additive effect between bupropion and citicoline on the generation of anxiolytic and antidepressant\u2011like behaviors in the nerve\u2011ligated mice. Based on these results, we concluded that there is a crosstalk between bupropion and citicoline in the control of anxiety\u2011 and depression\u2011like behaviors in the nerve\u2011ligated mice.<\/jats:p>","DOI":"10.55782\/c6vq8k73","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:15:38Z","timestamp":1772010938000},"source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological modulation of anxiety\u2011like and depression\u2011like behaviors in nerve\u2011ligated mice: regarding the effects of citicoline and bupropion"],"prefix":"10.55782","author":[{"family":"Bardia Hajikarimloo","sequence":"first","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Negar Raissi-Dehkordi","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nastaran Raissi-Dehkordi","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mohammad-Reza Zarrindast","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Khakpai","sequence":"additional","affiliation":[{"name":"Department of Physiology, TeMS.C., Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2026,2,23]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2737\/2545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2737\/2545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:15:38Z","timestamp":1772010938000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.55782\/c6vq8k73","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}