{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:45:20Z","timestamp":1773215120502,"version":"3.50.1"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Seizures in epilepsy result from excessive neuronal electrical discharges. Imbalances in potassium homeostasis can increase neuronal excitability and trigger epileptic seizures. Drugs that enhance potassium currents are expected to suppress seizures. Pinacidil, an ATP\u2011sensitive potassium channel opener, has shown anticonvulsant effects in acute seizure models in rodents. However, its effects following chronic systemic administration in pentylenetetrazole (PTZ)-kindled rats remain unknown. The aim of this study was to investigate the impact of long\u2011term pinacidil treatment in the PTZ\u2011kindling model of epilepsy. Male Wistar Hannover rats were treated intraperitoneally with pinacidil 30 min before each PTZ injection, administered intraperitoneally every other day for 27 days (14 injections). Behavioral responses were recorded for 30 min immediately after each PTZ injection. Twenty\u2011four hours after the last PTZ injection, animals underwent the rotarod test and were then euthanized for toxicological analysis of renal and hepatic biochemical markers in serum. Chronic pinacidil treatment prevented the development of PTZ\u2011induced kindling. Biochemical data showed that chronic pinacidil did not provoke changes in serum creatinine and urea levels or in aspartate aminotransferase and alanine aminotransferase levels. These findings suggest that long\u2011term administration of pinacidil impairs the progression of PTZ\u2011induced kindling without causing nephrotoxic or hepatotoxic effects.<\/jats:p>","DOI":"10.55782\/d9kdzx42","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:51:10Z","timestamp":1773136270000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic pinacidil attenuates the pentylenetetrazole\u2011induced kindling in rats"],"prefix":"10.55782","author":[{"given":"Artur Teixeira","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Biotechnology, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil; Medical School, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica Aparecida","family":"Gelfuso","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Luciano","family":"Falconi-Sobrinho","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil; Medical School, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8407-8865","authenticated-orcid":true,"given":"Rene Oliveira","family":"Beleboni","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil; Medical School, University of Ribeir\u00e3o Preto, Ribeir\u00e3o Preto S\u00e3o Paulo, Brazil; Carlos Chagas Institute \u2013 Fiocruz\u2011PR, Curitiba Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2026,2,27]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2724\/2547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2724\/2547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:51:10Z","timestamp":1773136270000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.55782\/d9kdzx42","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}